2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Betacellulin
  6. Betacellulin/BTC Protein, Mouse (HEK293, His-hFc)

Betacellulin/BTC Protein, Mouse (HEK293, His-hFc)

Art. -Nr.: HY-P75478
Handling Instructions Technical Support

Betacellulin/BTC Protein, a growth factor with affinity for EGFR, ERBB4, and other EGF receptor family members, exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Its molecular activity involves interactions with EGFR and ERBB4, contributing to cellular signaling and regulation. Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

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Beschreibung

Betacellulin/BTC Protein, a growth factor with affinity for EGFR, ERBB4, and other EGF receptor family members, exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Its molecular activity involves interactions with EGFR and ERBB4, contributing to cellular signaling and regulation. Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
Background

Betacellulin/BTC Protein is a growth factor exhibiting affinity for EGFR, ERBB4, and other members of the EGF receptor family. It exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells, functioning as a monomer. Its molecular activity involves interactions with both EGFR and ERBB4, contributing to its role in cellular signaling and regulation.
Species

Mouse
Source

HEK293
Tag

C-hFc;C-His
Accession

Q05928 (D32-Q118)
Gene ID

12223  [NCBI]
Molecular Construction
N-term
BTC (D32-Q118)
Accession # Q05928
hFc-His
C-term
Protein Length

Extracellular Domain
Synonyms
Btc; Betacellulin; Betacellulin epidermal growth factor family member
AA Sequence

DGNTTRTPETNGSLCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGARCERVDLFYLQQDRGQ

Predicted Molecular Mass
38 kDa
Molekulargewicht

Approximately 50-55 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Reinheit

≥ 90%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Dokumentation
Handling Instructions (2659 KB)

Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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