1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR-IN-71

EGFR-IN-71 

Cat. No.: HY-150781
Handling Instructions

EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma.

For research use only. We do not sell to patients.

EGFR-IN-71 Chemical Structure

EGFR-IN-71 Chemical Structure

CAS No. : 2676155-98-7

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Description

EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1].

IC50 & Target

IC50: 3.7 μM (EGFR)[1]

In Vitro

EGFR-IN-71 (compound 41) (0-100 μM; 72 h) has inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines with IC50s of 9.1 μM, 16 μM, 0.48 μM, 25 μM, 0.96 μM and 8.0 μM, respectively.
Molecular Weight

405.62

Formula

C16H9ClIN3

CAS No.
SMILES

IC1=CC2=NC=NC(NC3=CC=C(Cl)C(C#C)=C3)=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR-IN-71
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HY-150781
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