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  3. EGF Superfamily
  4. Betacellulin
  5. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc)

Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc)

Cat. No.: HY-P77303
Handling Instructions

Betacellulin/BTC Protein, a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. In addition, BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is 111 a.a., with molecular weight of ~46 kDa.

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Description

Betacellulin/BTC Protein, a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. In addition, BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is 111 a.a., with molecular weight of ~46 kDa.

Background

Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. BTC functions as a ligand for the epidermal growth factor receptor (EGFR) and is expressed in a variety of cell types and tissues. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. BTC exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors, which may increase IRS-2 expression, contributing to the regeneration of beta cells[1].

Species

Cynomolgus

Source

HEK293

Tag

C-hFc

Accession

XP_001101880.3 (M1-Y111)

Gene ID

702178  [NCBI]

Molecular Construction
N-term
BTC (M1-Y111)
Accession # XP_001101880
hFc
C-term
Synonyms
Btc; Betacellulin; Betacellulin epidermal growth factor family member
Molecular Weight

Approximately 46 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc)
Cat. No.:
HY-P77303
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