2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. WB518

WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17.

For research use only. We do not sell to patients.

WB518 Chemical Structure

WB518 Chemical Structure

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WB518 Related Antibodies

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Description

WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17[1].

IC50 & Target

STAT3

 

p-STAT3

 

In Vitro

WB518 (5-25 μM) significantly reduces the mRNA and protein levels of Keratin 17 (K17) in HaCaT cells by inhibiting the phosphorylation of STAT3 Tyr705 (Y705)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WB518 Related Antibodies

Western Blot Analysis[1]

Cell Line: HaCaT cells
Concentration: 0, 5, 25 μM
Incubation Time: 12 h
Result: Decreased K17 mRNA levels following stimulation with IL-22 (100 ng/ml) or IL-17A (300 U/ml) compared to untreated cells. Concentration-dependently down-regulated K17 protein expression by inhibiting STAT3 activation, without affecting the ERK or STAT1 pathway.
In Vivo

WB518 (17.5 μg and 35 μg per site, External application, daily, for 5 days) ameliorates TPA (HY-18739)-induced psoriasis-like skin inflammation, anss significantly improves the phenotypic characteristics of mouse psoriasis models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (6–8 weeks old)[1]
Dosage: 17.5 μg and 35 μg per site
Administration: External application, daily, for 5 days
Result: WB518 (35 μg) exhibited significantly reduced epidermal hyperplasia and dermal infiltration of inflammatory cells compared to mice treated with TPA alone.
Molecular Weight

518.34

Formula

C20H16BrN5O5S
SMILES

COC(C1CN(CC2=C1C(C#N)=C(S2)NC(C3=CN(N=C3)C)=O)C(C4=CC=C(O4)Br)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WB518 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WB518WB 518WB-518STATPsoriasisanti-psoriasisHaCaT cellsepidermal hyperplasiaKeratin 17Inhibitorinhibitorinhibit

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