1. Apoptosis
  2. Apoptosis
  3. Sclareol

Sclareol 

Cat. No.: HY-N0128 Purity: ≥98.0%
Handling Instructions

Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis.

For research use only. We do not sell to patients.

Sclareol Chemical Structure

Sclareol Chemical Structure

CAS No. : 515-03-7

Size Price Stock Quantity
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis[1].

In Vitro

Sclareol is cytotoxic to 13 of 14 human leukemia cell lines tested, with IC50 values ranging from 6.0–24.2 μg/mL, but is not cytotoxic to peripheral blood mononuclear leukocytes within the same dose range[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.50

Formula

C₂₀H₃₆O₂

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (324.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2415 mL 16.2075 mL 32.4149 mL
5 mM 0.6483 mL 3.2415 mL 6.4830 mL
10 mM 0.3241 mL 1.6207 mL 3.2415 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SclareolApoptosisSalvia sclarea leukemiaP-388human epidermal?carcinoma?cellapoptosisInhibitorinhibitorinhibit

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Sclareol
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HY-N0128
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