2. Search Result
Search Result
Results for "

P-388

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

3

Peptides

22

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2835
    Alboctalol

    		Others Others
    Alboctalol can be isolated from Morus australis. Alboctalol has weak cytotoxicity against P-388 cells .
    Alboctalol
  • HY-118726
    Luotonin F

    		Topoisomerase Cancer
    Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .
    Luotonin F
  • HY-N3123
    Oxychelerythrine

    Dihydrooxochelerythrine

    		 Others Cancer
    Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED50s of 3.25 and 5.48 μg/mL, respectively .
    Oxychelerythrine
  • HY-N9210
    1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid

    		Others Cancer
    1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid, a ellagic acid derivative of Agrostistachys hookeri, exhibits activity against cultured P-388 lymphocytic leukemia cells .
    1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid
  • HY-N1631
    1-Hydroxyrutecarpine

    1-Hydroxyrutaecarpine

    		 Others Others
    1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity .
    1-Hydroxyrutecarpine
  • HY-N1655
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether

    		Others Cancer
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether is a biflavonoid, which can be isolated from the aerial parts of Selaginella delicatula. 2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities against P-388 and HT-29 cell lines, with ED50 (median effective dose) values of 3.50 and 5.25 µg/mL, respectively .
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether
  • HY-N7011
    Epicorynoxidine

    		Others Inflammation/Immunology
    Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED50 of 25.53 μg/mL .
    Epicorynoxidine
  • HY-12458
    Pyrindamycin A

    		DNA/RNA Synthesis Infection Cancer
    Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml .
    Pyrindamycin A
  • HY-N7321A
    (R)-Eucomol

    		Bacterial Infection Cancer
    (R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells .
    (R)-Eucomol
  • HY-108603
    Bryostatin 2

    (+)-Bryostatin 2

    		 Others Cancer
    Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic leukemia .
    Bryostatin 2
  • HY-N6955
    Eupalinilide B

    		Others Cancer
    Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .
    Eupalinilide B
  • HY-N12151
    Chaparrinone

    		Parasite Infection
    Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively) .
    Chaparrinone
  • HY-142102
    T988C

    (+)-T988C

    		 Others Cancer
    T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .
    T988C
  • HY-N8979
    Kanshone A

    		Others Inflammation/Immunology
    Kanshone A is a sesquiterpene isolated from the roots of Nardostachys chinensis (Valerianaceae). Kanshone A shows cytotoxic with an IC50 value of 7.0 µg/ml in P388 cells .
    Kanshone A
  • HY-161239A
    IB-96212

    		Antibiotic Infection Cancer
    IB-96212 (compound 5) is a member of oligomycin class which can be extracted ftom the marine Micromonospora sp. L-25-ES25-008 ref. IB-96212 is an antitumor antibiotic against P-388, it also exhibits antimicrobial activity against Micrococcus luteus .
    IB-96212
  • HY-N3308
    Medicarpin

    		Apoptosis Cancer
    Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .
    Medicarpin
  • HY-12459
    Pyrindamycin B

    		Bacterial Infection
    Pyrindamycin B is an antibiotic, actives against gram-positive and gram-negative bacterias, and exhibits strong therapeutic effects against both agent-sensitive and resistant cells of P388 leukemia in mice .
    Pyrindamycin B
  • HY-N3041
    Plumieride

    Agoniadin; NSC 609065

    		 Fungal Infection Cancer
    Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL .
    Plumieride
  • HY-N0840
    Bruceantin
    1 Publications Verification

    (-)-Bruceantin; NCI165563; NSC165563

    		 Others Cancer
    Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.
    Bruceantin
  • HY-N10350
    2,3-Dihydro-3-methoxywithaferin A

    		Others Cancer
    2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells[1].
    2,3-Dihydro-3-methoxywithaferin A
  • HY-120504
    N-Acetyltyramine

    		Bacterial Infection Cancer
    N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .
    N-Acetyltyramine
  • HY-N1649
    2,3,2'',3''-Tetrahydroochnaflavone

    		Others Cancer
    2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC50 of 8.2 µg/mL .
    2,3,2'',3''-Tetrahydroochnaflavone
  • HY-19839
    Ansamitocin P 3'

    Antibiotic C 15003P3'; Maytansinol butyrate
    Ansamitocin P 3' (Antibiotic C 15003P3') is an anti-tumor antibiotic. Ansamitocin P 3' prolongs the survival of mice with leukemia P388, melanoma B16, leukemia L1210, sarcoma 180, Ehrlich carcinoma and mast cell tumor P815 .
    Ansamitocin P 3'
  • HY-18351
    Indotecan

    LMP-400; NSC-724998

    		 Topoisomerase Infection Cancer
    Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis .
    Indotecan
  • HY-121123
    Adamantanine

    2-Aminoadamantane-2-carboxylic acid

    		 Aminopeptidase Cancer
    Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5 .
    Adamantanine
  • HY-N10206
    11-epi-Chaetomugilin I

    		Endogenous Metabolite Cancer
    11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
    11-epi-Chaetomugilin I
  • HY-P3116
    Thiocoraline

    		Bacterial Cancer
    Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms .
    Thiocoraline
  • HY-N10208
    Aspericin C

    		Endogenous Metabolite Cancer
    Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC50=14.6, 7.1, 61.4, and 24.2 μM, respectively) .
    Aspericin C
  • HY-146497
    Topoisomerase I inhibitor 7

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones .
    Topoisomerase I inhibitor 7
  • HY-N0128
    Sclareol
    1 Publications Verification

    		 Apoptosis Cancer
    Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .
    Sclareol
  • HY-18970
    TG6-129

    TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages .
    TG6-129
  • HY-N8435
    Desoxo-narchinol A

    		TNF Receptor COX NO Synthase PGE synthase Infection Inflammation/Immunology
    Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research .
    Desoxo-narchinol A
  • HY-105172
    TT-232

    CAP-232; TLN-232

    		 Somatostatin Receptor Inflammation/Immunology Cancer
    TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent .
    TT-232
  • HY-119458
    Luotonin A

    		Topoisomerase TMV Fungal Infection
    Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity .
    Luotonin A
  • HY-N3376
    Liriodenine

    Spermatheridine; VLT045

    		 Apoptosis Cancer
    Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .
    Liriodenine
  • HY-N2306A
    Aclacinomycin A hydrochloride

    Aclarubicin hydrochloride

    		 Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic Cancer
    Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .
    Aclacinomycin A hydrochloride
  • HY-W505771
    Seselin

    		Fungal Infection Inflammation/Immunology Cancer
    Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active .
    Seselin

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: