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Cat. No.: HY-N3376

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Liriodenine

(Synonyms: Spermatheridine; VLT045)

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Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9.

For research use only. We do not sell to patients.

Purity: 97%
CAS No.: 475-75-2
Formula: C₁₇H₉NO₃
Molecular Weight:275.26

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Liriodenine Chemical Structure

CAS No.: 475-75-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities^[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	0.72 μg/mL Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 2292689]
B16-F10	IC₅₀	>10 μM Compound: 20	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
BV-2	IC₅₀	5 μM Compound: 13	Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay	[PMID: 33822610]
HCT-8	ED₅₀	0.7 μg/mL Compound: 1	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 2292689]
HepG2	IC₅₀	8.3 μM Compound: 20	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
HL-60	IC₅₀	5.5 μM Compound: 20	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
HT-29	IC₅₀	>10 μM Compound: 6	Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 3 days by SRB assay	[PMID: 23327794]
K562	IC₅₀	5 μM Compound: 20	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
KB	ED₅₀	1 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 2292689]
KB	ED₅₀	3.1 μg/mL Compound: liriodenine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	10.1021/np50019a011
KB	IC₅₀	5 μM Compound: 9	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
L1210	ED₅₀	2.33 μg/mL Compound: 1	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 2292689]
MCF7	IC₅₀	5 μM Compound: 9	Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
NCI-H460	IC₅₀	5 μM Compound: 9	Cytotoxicity against human NCI-H460 cells after 3 days by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
P388	ED₅₀	0.57 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 2292689]
PBMC	IC₅₀	34.8 μM Compound: 20	Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 27300257]
RAW264.7	IC₅₀	1.39 μM Compound: 129	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 33454546]
RAW264.7	IC₅₀	10.5 μM Compound: 10	Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 33939429]
RAW264.7	IC₅₀	34.7 μM Compound: 6	Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 32247751]
SF-268	IC₅₀	5 μM Compound: 9	Cytotoxicity against human SF268 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SF268 cells after 3 days by sulforhodamine B assay	[PMID: 19874044]
Vero	CC₅₀	48 μM Compound: 16	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 9584402]

In Vitro

Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC₅₀ values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 475-75-2
Appearance Solid
Molecular Weight 275.26
Formula C₁₇H₉NO₃
Color Light yellow to yellow
SMILES

O=C1C2=CC=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53
Synonyms

Spermatheridine; VLT045
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol [Content Brief]

[2]. Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug Des Devel Ther [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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