7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

  • J Nat Prod. 2016 Jun 24;79(6):1524-31. doi: 10.1021/acs.jnatprod.5b01037.
Emmanoel V Costa  1 ,  Maria Lúcia B Pinheiro  1 ,  Beatriz Helena L N S Maia  2 ,  Francisco A Marques  2 ,  Ana Lúcia T G Ruiz  3 ,  Gabriela M Marchetti  3 ,  João Ernesto de Carvalho  3 ,  Milena B P Soares  4  5 ,  Cinara O S Costa  4 ,  Alexandre F C Galvão  4 ,  Norberto P Lopes  6 ,  Hector H F Koolen  7 ,  Daniel P Bezerra  4 ,  Andersson Barison  2
Affiliations
  • 1. Department of Chemistry, Federal University of Amazonas , Manaus 69077-000, Brazil.
  • 2. Department of Chemistry, Federal University of Paraná , Curitiba 81531-990, Brazil.
  • 3. Chemical, Biological and Agricultural Pluridisciplinary Research Center/CPQBA, University of Campinas , Paulínia 13083-970, Brazil.
  • 4. Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.
  • 5. Biotechnology and Cell Therapy Center, São Rafael Hospital , Salvador 41253-190, Brazil.
  • 6. Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo , Ribeirão Preto 14040-903, Brazil.
  • 7. DeMpSter Mass Spectrometry Group, Amazonas State University , Manaus 69050-010, Brazil.
PMID: 27300257 DOI: 10.1021/acs.jnatprod.5b01037
Abstract

Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known Alkaloids (13-21). The structures of the new Alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.