475-75-2
475-75-2
Chemical Structure
Liriodenine
Synonym(s): Spermatheridine; VLT045
- No. CAS: 475-75-2
- Formula:C17H9NO3
- Molecular Weight:275.26
IUPAC Name: 8H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinolin-8-one
InChIKey: MUMCCPUVOAUBAN-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53
Biological Activity: Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Liriodenine | 97% | Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9. | ||||||||||||||||||||
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Lanuginosine | 98.27% | Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease. | ||||||||||||||||||||
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Lysicamine | 99.34% | Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity. | ||||||||||||||||||||
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O-Methylmoschatoline | O-Methylmoschatoline (Liridine) is a compound with notable bioactivity, exhibiting potential applications in medicinal chemistry. | |||||||||||||||||||||
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Bianfugedine | Bianfugedine is an alkaloid found in the dried rhizomes of Menispermum dauricum DC. | |||||||||||||||||||||
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Dicentrinone | Dicentrinone is an orally active PDI inhibitor with an IC50 value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis. | |||||||||||||||||||||
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Oxonantenine | Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis. | |||||||||||||||||||||
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Lauterine | Lauterine is an alkaloid that can be isolated from Laurelia novae-zelandiae. | |||||||||||||||||||||
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Machigline | Machigline is a natural product. | |||||||||||||||||||||
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Liriodenine methiodide | Liriodenine methiodide is an antibiotic that is active against C. albicans and S. cereuisiae with antimicrobial activities. | |||||||||||||||||||||
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Oxocrebanine | Oxocrebanine, an aporphine alkaloid, can be found in Fissistigma poilanei (Annonaceae). | |||||||||||||||||||||
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References
- [1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol [Content Brief]
- [2]. Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug Des Devel Ther [Content Brief]
