Bioactive constituents of the stem bark of Mitrephora glabra

  • J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.
Chen Li  1 ,  Dongho Lee ,  Tyler N Graf ,  Sharnelle S Phifer ,  Yuka Nakanishi ,  Soedarsono Riswan ,  Fransisca M Setyowati ,  Achmad M Saribi ,  Djaja D Soejarto ,  Norman R Farnsworth ,  Joseph O Falkinham 3rd ,  David J Kroll ,  A Douglas Kinghorn ,  Mansukh C Wani ,  Nicholas H Oberlies
Affiliations
  • 1. Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
PMID: 19874044 DOI: 10.1021/np900572g
Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of Cancer cell lines and a battery of Microorganisms.