1. Cell Cycle/DNA Damage
  2. Topoisomerase

Indotecan 

Cat. No.: HY-18351
Handling Instructions

Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

For research use only. We do not sell to patients.

Indotecan Chemical Structure

Indotecan Chemical Structure

CAS No. : 915303-09-2

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View All Topoisomerase Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

IC50 & Target

IC50:300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0899 mL 10.4495 mL 20.8991 mL
5 mM 0.4180 mL 2.0899 mL 4.1798 mL
10 mM 0.2090 mL 1.0450 mL 2.0899 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

478.49

Formula

C₂₆H₂₆N₂O₇

CAS No.

915303-09-2

SMILES

O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6CCOCC6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Indotecan
Cat. No.:
HY-18351
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Indotecan

Cat. No.: HY-18351