Desoxo-narchinol A
Based on 1 Customer Validation
Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 53859-06-6
- Formula: C12H16O2
- Molecular Weight:192.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
2.04 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| BV-2 | IC50 |
2.05 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
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[PMID: 29221883] |
| BV-2 | IC50 |
2.11 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| BV-2 | IC50 |
3.48 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA
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[PMID: 29221883] |
| BV-2 | IC50 |
3.57 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| Microglia | IC50 |
3.18 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| Microglia | IC50 |
3.62 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| Microglia | IC50 |
4.96 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA
Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA
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[PMID: 29221883] |
| Microglia | IC50 |
5.33 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
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[PMID: 29221883] |
| Microglia | IC50 |
5.84 μM
Compound: 3
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Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
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[PMID: 29221883] |
| RAW264.7 | IC50 |
8.4 μM
Compound: 4
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
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[PMID: 22079762] |
Desoxo-narchinol A inhibits tissue injury and production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the liver and lung[2].
Desoxo-narchinol A (0-500 nM, 24 h) inhibits the production of inflammatory mediators, such as iNOS and its derivative NO, COX-2, PGE2, IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages[2].
Desoxo-narchinol A inhibits LPS-induced activation of p38 in murine macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice[3]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53859-06-6
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Appearance Solid
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Molecular Weight 192.25
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Formula C12H16O2
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Color White to off-white
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SMILES
C[C@@]1([C@@H](C=C2)O)C(C2=O)=CCC[C@H]1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Itokawa H, et al. Cytotoxic sesquiterpenes from Nardostachys chinensis. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4. [Content Brief]
[2]. Shin JY, et al. Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide. Int Immunopharmacol. 2015 Dec;29(2):730-738. [Content Brief]
[3]. Thapa SK, Upadhyay M, Kim TH, Shin S, Park SJ, Shin BS. Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice. Molecules. 2019 May 28;24(11):2037. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desoxo-narchinol A Related Classifications
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