1. Apoptosis
    Immunology/Inflammation
  2. TNF Receptor
    COX
    NO Synthase
    PGE synthase
  3. Desoxo-narchinol A

Desoxo-narchinol A 

Cat. No.: HY-N8435
Handling Instructions

Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research.

For research use only. We do not sell to patients.

Desoxo-narchinol A Chemical Structure

Desoxo-narchinol A Chemical Structure

CAS No. : 53859-06-6

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Description

Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research[1][2][3].

In Vitro

Desoxo-narchinol A inhibits tissue injury and production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the liver and lung[2].
Desoxo-narchinol A (0-500 nM, 24 h) inhibits the production of inflammatory mediators, such as iNOS and its derivative NO, COX-2, PGE2, IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages[2].
Desoxo-narchinol A inhibits LPS-induced activation of p38 in murine macrophages[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Desoxo-narchinol A (0-0.5 mg/kg, IP, once) dramatically reduced mortality in a murine LPS-induced endotoxin shock model[2].
Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

192.25

Formula

C12H16O2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Desoxo-narchinol A
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