Cytotoxic sesquiterpenes from Nardostachys chinensis

  • Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4. doi: 10.1248/cpb.41.1183.
H Itokawa  1 ,  K Masuyama ,  H Morita ,  K Takeya
Affiliations
  • 1. Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
PMID: 8370115 DOI: 10.1248/cpb.41.1183
Abstract

Five cytostatic Sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.

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