2. Anti-infection
  3. Fungal
  4. Seselin

Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.

For research use only. We do not sell to patients.

Seselin Chemical Structure

Seselin Chemical Structure

CAS No. : 523-59-1

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Seselin Related Antibodies

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Description

Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active[1][2][3].

In Vitro

Seselin shows cytotoxic effects with ED50 of 8.66 and 9.94 μg/mL against P-388 and HT-29 cells, respectively[1].
Seselin (5-20 μM; 0.5-24 h) inhibits cytokine output from macrophages stimulated by LPS and IFN-γ dose- and time-dependently[3].
Seselin (5-20 μM; 12 h) inhibits the expression of proinflammatory macrophage markers (iNOS, phagocytosis, CD11c) in BMDMs[3].
Seselin (5-20 μM; 0.5-6 h) blocks the STAT1 signalling pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Seselin Related Antibodies

RT-PCR[3]

Cell Line: Bone marrow-derived macrophages (BMDMs)
Concentration: 5, 10 and 20 μM
Incubation Time: 6 h
Result: Reduced the mRNA for cytokines (IL-1β, IL-6, Tnf-α and IL-23) and chemokines (Ccl3, Ccl7, Cxcl9 and Cxcl11) concentration-dependently in BMDMs.

Western Blot Analysis[3]

Cell Line: BMDMs
Concentration: 5, 10 and 20 μM
Incubation Time: 0.5, 1.5, 3 and 6 h
Result: Suppressed expression of p-STAT1 and p-p65 both concentration and time dependently.
In Vivo

Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice[2]
Dosage: 0.5, 4.5 or 40.5 mg/kg
Administration: Subcutaneous injection; once
Result: Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.
Animal Model: C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model[3]
Dosage: 3, 10 and 30 mg/kg
Administration: Intragastric administration, once
Result: Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.
Molecular Weight

228.24

Formula

C14H12O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1(C=CC2=C(O1)C=CC3=C2OC(=O)C=C3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.48%

COA (253 KB) HNMR (100 KB) LCMS (286 KB)

Handling Instructions (2659 KB)
References
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Seselin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seselin523-59-1FungalP-388HT-29BMDMsiNOSphagocytosisCD11cCcl3Ccl7Cxcl9Cxcl11IL-1βIL-6Tnf-αIL-23Inhibitorinhibitorinhibit

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