Bioactive Phenolic Components from the Twigs of Atalantia buxifolia

  • J Nat Prod. 2018 Jul 27;81(7):1534-1539. doi: 10.1021/acs.jnatprod.7b00938.
Fang-Rong Chang  1 ,  Pei-Shian Li ,  Rosa Huang Liu  2 ,  Hao-Chun Hu ,  Tsong-Long Hwang  3 ,  Jin-Ching Lee ,  Shu-Li Chen ,  Yang-Chang Wu  4 ,  Yuan-Bin Cheng  4
Affiliations
  • 1. National Research Institute of Chinese Medicine , Taipei 112 , Taiwan.
  • 2. School of Nutrition, College of Health Care and Management , Chung Shan Medical University , Taichung 402 , Taiwan.
  • 3. Graduate Institute of Natural Products, College of Medicine , Chang Gung University , Taoyuan 333 , Taiwan.
  • 4. Department of Medical Research , Kaohsiung Medical University Hospital , Kaohsiung 807 , Taiwan.
PMID: 29975532 DOI: 10.1021/acs.jnatprod.7b00938
Abstract

Five new compounds named buxifoximes A-C (1-3), buxifobenzoate (4), and 7- O-(7'-peroxygeranyl) coumarin (5), together with 25 known compounds, were identified from the twigs of Atalantia buxifolia. Compounds 1-3 are unique secondary metabolites with the aldoxime functionality. The structures of the isolates were determined on the basis of spectroscopic data analyses, and the structure of 1 was confirmed by an X-ray single-crystallographic analysis. With respect to bioactivity, antidengue virus, anti-inflammatory, and cytotoxic activities of all purified compounds were tested and evaluated. Compound 1 showed a significant anti-inflammatory effect by inhibiting superoxide anion generation with an IC50 value of 4.8 ± 0.7 μM. Among the Acridone Alkaloids, 5-hydroxy- N-methylseverifoline (23) exhibited antidengue activity (IC50 = 5.3 ± 0.4 μM), and atalaphyllinine (20) demonstrated cytotoxicity (IC50 = 6.5 ± 0.0 μM) against the human liver Cancer cell line, HepG2.