Luotonin A

Cat. No.: HY-119458: Data Sheet
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Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.

For research use only. We do not sell to patients.

Luotonin A Chemical Structure

CAS No. : 205989-12-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Topoisomerase Topo I Topo II DNA gyrase

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	61.25 μM Compound: 10	Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x
CCRF-CEM	GI₅₀	≥40 μM Compound: 1a, luotonin A	Growth inhibition of human CEM cells by Alamar blue assay Growth inhibition of human CEM cells by Alamar blue assay	[PMID: 17418582]
CEM/C2	GI₅₀	>40 μM Compound: 1a, luotonin A	Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay	[PMID: 17418582]
HCT-116	IC₅₀	51.11 μM Compound: 36	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation	[PMID: 36375335]
HEK293	IC₅₀	58 μM Compound: 1	Cytotoxicity against HEK cells after 72 hrs by MTT assay Cytotoxicity against HEK cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of HeLa cells after 4 days Growth inhibition of HeLa cells after 4 days	[PMID: 17418582]
HeLa	IC₅₀	5.94 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	IC₅₀	6.4 μM Compound: 1	Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis	[PMID: 25757092]
HeLa	IC₅₀	3 μM Compound: 36	Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 36375335]
HL-60	IC₅₀	>100 μM Compound: 36	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36375335]
K562	IC₅₀	28.8 μM Compound: 1	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 25757092]
MCF7	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of MCF7 cells after 4 days Growth inhibition of MCF7 cells after 4 days	[PMID: 17418582]
MCF7	GI₅₀	5 μM Compound: 1a, luotonin A	Growth inhibition of adriamycin-resistant MCF7 cells after 4 days Growth inhibition of adriamycin-resistant MCF7 cells after 4 days	[PMID: 17418582]
MCF7	IC₅₀	9.28 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25757092]
MCF7	IC₅₀	3 μM Compound: 36	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay	[PMID: 36375335]
NCI/ADR-RES	IC₅₀	3 μM Compound: 36	Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 36375335]
NCI-H460	IC₅₀	67 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)	[PMID: 15501036]
NCI-H460	IC₅₀	7.7 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)	[PMID: 15501036]
NCI-H460	IC₅₀	7.7 μM Compound: 36	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 36375335]
P388	IC₅₀	1.8 μg/mL Compound: 1 (luotonin A)	Cytotoxic activity against mouse leukemia P-388 cells Cytotoxic activity against mouse leukemia P-388 cells	[PMID: 14980663]
P388	IC₅₀	1.8 μg/mL Compound: Luotonin A	Cytotoxicity against mouse P388 cells assessed as reduction in cell growth Cytotoxicity against mouse P388 cells assessed as reduction in cell growth	[PMID: 30917303]
P388	IC₅₀	6.3 μM Compound: 53	Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition	[PMID: 35413618]
P388	IC₅₀	1.8 μg/mL Compound: 36	Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 36375335]
SK-N-SH	IC₅₀	61.08 μM Compound: 10	Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x

Molecular Weight

285.30

Formula

C₁₈H₁₁N₃O

CAS No.

205989-12-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(C3=C(C2)C=C4C(C=CC=C4)=N3)=NC5=CC=CC=C51

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 2.5 mg/mL (8.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5051 mL	17.5254 mL	35.0508 mL
5 mM	0.7010 mL	3.5051 mL	7.0102 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (274 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773. [Content Brief]

[2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5051 mL	17.5254 mL	35.0508 mL	87.6271 mL
DMSO	5 mM	0.7010 mL	3.5051 mL	7.0102 mL	17.5254 mL

Luotonin A Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luotonin A205989-12-4TopoisomeraseFungalTMVTobacco mosaic virustobacco mosaic virusPeganum nigellastrum BungeP-388Inhibitorinhibitorinhibit

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Luotonin A

Customer Review

Luotonin A Related Antibodies

Featured Recommendations

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•Related Small Molecules:

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View All Topoisomerase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Luotonin A Related Classifications

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Customer Review

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