2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Fungal TMV
  4. Luotonin A

Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.

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Luotonin A

Luotonin A Chemical Structure

CAS No. : 205989-12-4

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Based on 1 publication(s) in Google Scholar

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Description

Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
61.25 μM
Compound: 10
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0018-x
CCRF-CEM GI50
>= 40 μM
Compound: 1a, luotonin A
Growth inhibition of human CEM cells by Alamar blue assay
Growth inhibition of human CEM cells by Alamar blue assay
[PMID: 17418582]
CEM/C2 GI50
> 40 μM
Compound: 1a, luotonin A
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
[PMID: 17418582]
HCT-116 IC50
51.11 μM
Compound: 36
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation
[PMID: 36375335]
HEK293 IC50
58 μM
Compound: 1
Cytotoxicity against HEK cells after 72 hrs by MTT assay
Cytotoxicity against HEK cells after 72 hrs by MTT assay
[PMID: 25757092]
HL-60 IC50
> 100 μM
Compound: 36
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36375335]
HeLa GI50
3 μM
Compound: 1a, luotonin A
Growth inhibition of HeLa cells after 4 days
Growth inhibition of HeLa cells after 4 days
[PMID: 17418582]
HeLa IC50
3 μM
Compound: 36
Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 36375335]
HeLa IC50
5.94 μM
Compound: 1
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 25757092]
HeLa IC50
6.4 μM
Compound: 1
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
[PMID: 25757092]
K562 IC50
28.8 μM
Compound: 1
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 25757092]
MCF7 GI50
3 μM
Compound: 1a, luotonin A
Growth inhibition of MCF7 cells after 4 days
Growth inhibition of MCF7 cells after 4 days
[PMID: 17418582]
MCF7 GI50
5 μM
Compound: 1a, luotonin A
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
[PMID: 17418582]
MCF7 IC50
3 μM
Compound: 36
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 5 days by MTT assay
[PMID: 36375335]
MCF7 IC50
9.28 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 25757092]
NCI-H460 IC50
67 μM
Compound: 1a
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
[PMID: 15501036]
NCI-H460 IC50
7.7 μM
Compound: 1a
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
[PMID: 15501036]
NCI-H460 IC50
7.7 μM
Compound: 36
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 36375335]
NCI/ADR-RES IC50
3 μM
Compound: 36
Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
Antiproliferative activity against human NCI-ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
[PMID: 36375335]
P388 IC50
1.8 μg/mL
Compound: 1 (luotonin A)
Cytotoxic activity against mouse leukemia P-388 cells
Cytotoxic activity against mouse leukemia P-388 cells
[PMID: 14980663]
P388 IC50
1.8 μg/mL
Compound: 36
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 36375335]
P388 IC50
1.8 μg/mL
Compound: Luotonin A
Cytotoxicity against mouse P388 cells assessed as reduction in cell growth
Cytotoxicity against mouse P388 cells assessed as reduction in cell growth
[PMID: 30917303]
P388 IC50
6.3 μM
Compound: 53
Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition
Antiproliferative activity gainst mouse P388 cells assessed as cell growth inhibition
[PMID: 35413618]
SK-N-SH IC50
61.08 μM
Compound: 10
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0018-x
Molecular Weight

285.30

Formula

C18H11N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(C3=C(C2)C=C4C(C=CC=C4)=N3)=NC5=CC=CC=C51
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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Luotonin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luotonin A205989-12-4TopoisomeraseFungalTMVTobacco mosaic virustobacco mosaic virusPeganum nigellastrum BungeP-388Inhibitorinhibitorinhibit

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