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Cat. No.: HY-P3116

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Thiocoraline

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC₅₀s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms.

For research use only. We do not sell to patients.

CAS No.: 173046-02-1
Formula: C₄₈H₅₆N₁₀O₁₂S₆
Molecular Weight:1157.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

Thiocoraline Chemical Structure

CAS No.: 173046-02-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.01 μM Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 26444379]
A549	GI₅₀	4.8 nM Compound: thiocoraline A	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 17571868]
DU-145	GI₅₀	1.9 nM Compound: thiocoraline A	Cytotoxicity against human DU145 cells after 72 hrs by SRB assay Cytotoxicity against human DU145 cells after 72 hrs by SRB assay	[PMID: 17571868]
HeLa	GI₅₀	1.3 nM Compound: thiocoraline A	Cytotoxicity against human HeLa cells after 72 hrs by SRB assay Cytotoxicity against human HeLa cells after 72 hrs by SRB assay	[PMID: 17571868]
HT-29	GI₅₀	3.9 nM Compound: thiocoraline A	Cytotoxicity against human HT29 cells after 72 hrs by SRB assay Cytotoxicity against human HT29 cells after 72 hrs by SRB assay	[PMID: 17571868]
K562	GI₅₀	1.3 nM Compound: thiocoraline A	Cytotoxicity against human K562 cells after 72 hrs by SRB assay Cytotoxicity against human K562 cells after 72 hrs by SRB assay	[PMID: 17571868]
LNCaP	GI₅₀	3 nM Compound: thiocoraline A	Cytotoxicity against human LNCaP cells after 72 hrs by SRB assay Cytotoxicity against human LNCaP cells after 72 hrs by SRB assay	[PMID: 17571868]
LoVo	GI₅₀	212.3 nM Compound: thiocoraline A	Cytotoxicity against doxorubicin resistant human LoVo cells after 72 hrs by SRB assay Cytotoxicity against doxorubicin resistant human LoVo cells after 72 hrs by SRB assay	[PMID: 17571868]
LoVo	GI₅₀	7.2 nM Compound: thiocoraline A	Cytotoxicity against human LoVo cells after 72 hrs by SRB assay Cytotoxicity against human LoVo cells after 72 hrs by SRB assay	[PMID: 17571868]
PANC-1	GI₅₀	2.5 nM Compound: thiocoraline A	Cytotoxicity against human PANC1 cells after 72 hrs by SRB assay Cytotoxicity against human PANC1 cells after 72 hrs by SRB assay	[PMID: 17571868]
SK-BR-3	GI₅₀	2.2 nM Compound: thiocoraline A	Cytotoxicity against human SK-BR3 cells after 72 hrs by SRB assay Cytotoxicity against human SK-BR3 cells after 72 hrs by SRB assay	[PMID: 17571868]
SK-MEL-28	GI₅₀	3 nM Compound: thiocoraline A	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by SRB assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by SRB assay	[PMID: 17571868]

Chemical Information

CAS No. 173046-02-1
Molecular Weight 1157.41
Formula C₄₈H₅₆N₁₀O₁₂S₆
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Romero F, et al. Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo). 1997 Sep;50(9):734-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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