Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities

  • J Antibiot (Tokyo). 1997 Sep;50(9):734-7. doi: 10.7164/antibiotics.50.734.
F Romero  1 ,  F Espliego ,  J Pérez Baz ,  T García de Quesada ,  D Grávalos ,  F de la Calle ,  J L Fernández-Puentes
Affiliations
  • 1. Drug Discovery Division, PharmaMar, S.A., Spain.
PMID: 9360617 DOI: 10.7164/antibiotics.50.734
Abstract

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive Microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.

Products