1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Proteasome
    Topoisomerase
  3. Aclacinomycin A hydrochloride

Aclacinomycin A hydrochloride (Synonyms: Aclarubicin hydrochloride)

Cat. No.: HY-N2306A Purity: 98.08%
Handling Instructions

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.

For research use only. We do not sell to patients.

Aclacinomycin A hydrochloride Chemical Structure

Aclacinomycin A hydrochloride Chemical Structure

CAS No. : 75443-99-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 448 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome[1]. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II[2]. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors[3].

IC50 & Target

20S proteasome[1].
Topoisomerase I and II[2].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (147.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1788 mL 5.8939 mL 11.7879 mL
5 mM 0.2358 mL 1.1788 mL 2.3576 mL
10 mM 0.1179 mL 0.5894 mL 1.1788 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

848.33

Formula

C₄₂H₅₄ClNO₁₅

CAS No.

75443-99-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Aclacinomycin A hydrochloride
Cat. No.:
HY-N2306A
Quantity:

Aclacinomycin A hydrochloride

Cat. No.: HY-N2306A