1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Proteasome
    Topoisomerase

Aclacinomycin A hydrochloride (Synonyms: Aclarubicin hydrochloride)

Cat. No.: HY-N2306A Purity: 98.08%
Handling Instructions

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.

For research use only. We do not sell to patients.

Aclacinomycin A hydrochloride Chemical Structure

Aclacinomycin A hydrochloride Chemical Structure

CAS No. : 75443-99-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 448 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
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Description

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome[1]. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II[2]. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors[3].

IC50 & Target

20S proteasome[1].
Topoisomerase I and II[2].

References
Molecular Weight

848.33

Formula

C₄₂H₅₄ClNO₁₅

CAS No.

75443-99-1

SMILES

O=C([[email protected]@H]1C2=CC(C(C3=CC=CC(O)=C43)=O)=C(C4=O)C(O)=C2[[email protected]@H](O[[email protected]@](O[[email protected]@H](C)[[email protected]]5O[[email protected]@](O[[email protected]@H](C)[[email protected]]6O[[email protected]](CCC7=O)([H])O[[email protected]]7C)([H])C[[email protected]@H]6O)([H])C[[email protected]@H]5N(C)C)C[[email protected]]1(O)CC)OC.Cl

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Aclacinomycin A hydrochloride
Cat. No.:
HY-N2306A
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Aclacinomycin A hydrochloride

Cat. No.: HY-N2306A