A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

  • Bioorg Med Chem Lett. 1998 Dec 1;8(23):3295-8. doi: 10.1016/s0960-894x(98)00603-9.
M Jung  1 ,  I Ko ,  S Lee ,  S J Choi ,  B H Youn ,  S K Kim
Affiliations
  • 1. Department of Chemistry, Yonsei University, Seoul, Korea.
PMID: 9873721 DOI: 10.1016/s0960-894x(98)00603-9
Abstract

A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human Cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.