1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
  2. Antibody-Drug Conjugate (ADC)
    Topoisomerase
  3. Datopotamab deruxtecan

Datopotamab deruxtecan (Synonyms: DS-1062; Dato-DXd)

Cat. No.: HY-141598
Handling Instructions

Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity.

For research use only. We do not sell to patients.

Datopotamab deruxtecan Chemical Structure

Datopotamab deruxtecan Chemical Structure

CAS No. : 2238831-60-0

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Description

Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
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Datopotamab deruxtecan
Cat. No.:
HY-141598
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