2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Topoisomerase
  4. Datopotamab deruxtecan

Datopotamab deruxtecan  (Synonyms: DS-1062; Dato-DXd)

Cat. No.: HY-141598 Purity: 99.54%
COA

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Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity.

For research use only. We do not sell to patients.

Datopotamab deruxtecan Chemical Structure

Datopotamab deruxtecan Chemical Structure

CAS No. : 2238831-60-0

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Based on 1 publication(s) in Google Scholar

Datopotamab deruxtecan Related Antibodies

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Description

Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Datopotamab deruxtecan Related Antibodies
In Vivo

Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Datopotamab deruxtecan]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.54%

COA (231 KB) RP-HPLC (197 KB)

Handling Instructions (2659 KB)
References
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Datopotamab deruxtecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Datopotamab deruxtecan2238831-60-0DS-1062 Dato-DXdDS1062DS 1062Antibody-Drug Conjugates (ADCs)TopoisomeraseAntibody-Drug ConjugatesTROP2ADCantitumorDeruxtecan,Inhibitorinhibitorinhibit

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