Enfortumab vedotin-ejfv (solution)
Based on 1 publication(s) in Google Scholar
Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate (ADC). Enfortumab vedotin-ejfv (solution) is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable Val-Cit linker. The antibody portion is Enfortumab (HY-P99016), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv (solution) is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma.
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- 純度: 99.78%
- CAS 番号: 1346452-25-2
- 分子量:152000 (average)
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Enfortumab vedotin-ejfv (solution)
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生物活性
Enfortumab vedotin-ejfv is a humanized, monoclonal ADC that binds to a protein expressed on the surface of cancer cells, Nectin-4. When Enfortumab vedotin-ejfv binds to Nectin-4 on cells, it is internalized into the cell which allows proteases to break down the linker and MMAE is released. MMAE impairs the microtubule network within the cell, blocking mitosis and subsequently leading to cell death[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1346452-25-2
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性状 Liquid
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分子量 152000 (average)
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Color Colorless to light yellow
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SMILES
[Enfortumab vedotin-ejfv (solution)]
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輸送条件
Shipping with dry ice.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Halford Z, et al. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. Ann Pharmacother. 2021;55(6):772-782. [Content Brief]
[2]. Mantia CM, et al. Enfortumab vedotin-ejfv for the treatment of advanced urothelial carcinoma. Expert Rev Anticancer Ther. 2022;22(5):449-455. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Enfortumab vedotin-ejfv (solution) 関連分類
HY-P99016B 関連分類
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- Enfortumab vedotin-ejfv (solution)
- 1346452-25-2
- Antibody-Drug Conjugates (ADCs)
- Nectin-4
- treatment‐related toxicity
- antibody-drug conjugate
- Enfortumab Vedotin
- nectin-4
- adverse events
- antibody drug conjugate
- enfortumab vedotin
- metastatic urothelial cancer
- urothelial carcinoma
- antibody–drug conjugates
- Antibody-drug conjugate
- MMAE
- Inhibitor
- inhibitor
- inhibit