2055109-19-6
Chemical Structure
ZW-49
- CAS No.: 2055109-19-6
- Formula:C33H32N8O3
- Molecular Weight:588.66
InChIKey: ICIBMWFVBWGWHU-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(N2C(C(C3=CC=CC=C3)=NC4=C2N=C(N=C4)NC5=CC=C(C=C5OC)N6CCN(CC6)C)=O)=CC=C1)=O
Biological Activity: ZW-49 is an orally active pan-EGFR inhibitor with IC50 values at 0.03-1.5 nM. ZW-49 inhibits all subgroups of EGFR mutations with selectivity over wild-type EGFR and other target families. ZW-49 blocks the ATP-binding pocket, occupies a conserved hydrophobic subpocket, avoids steric conflicts with PACC mutation P loops. ZW-49 inhibits cancer cells proliferation, induces G0/G1 phase cell-cycle arrest and apoptosis, and demonstrates anti-proliferative activity in xenograft mice models. ZW-49 can be used for the research of cancer, such as non-small cell lung cancer[1].
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ZW-49 | ZW-49 is an orally active pan-EGFR inhibitor with IC50 values at 0.03-1.5 nM. ZW-49 inhibits all subgroups of EGFR mutations with selectivity over wild-type EGFR and other target families. ZW-49 blocks the ATP-binding pocket, occupies a conserved hydrophobic subpocket, avoids steric conflicts with PACC mutation P loops. ZW-49 inhibits cancer cells proliferation, induces G0/G1 phase cell-cycle arrest and apoptosis, and demonstrates anti-proliferative activity in xenograft mice models. ZW-49 can be used for the research of cancer, such as non-small cell lung cancer. | |||||||||||||||||||||
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