1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
    Btk
  3. Sunvozertinib

Sunvozertinib 

Cat. No.: HY-132842
Handling Instructions

Sunvozertinib is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52).

For research use only. We do not sell to patients.

Sunvozertinib Chemical Structure

Sunvozertinib Chemical Structure

CAS No. : 2370013-12-8

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Description

Sunvozertinib is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)[1].

IC50 & Target[1]

EGFR exon 20 insertion

20.4 nM (IC50)

EGFRL858R/T790M

1.1 nM (IC50)

Her2 Exon20 YVMA

7.5 nM (IC50)

In Vitro

Sunvozertinib shows GI50s of 60.4, 83.2, 3.3, 101.3, and 47.1 nM for EGFR exon NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively. Sunvozertinib shows GI50s of 3.2, 5.8, 51.3, and 1983.5 nM for BTK WT OCI-LY-10, BTK WT TMD-8, BTK WT Ri-1, and non-BCR activated DB, respectively[1].
Sunvozertinib inhibits p-BTK with IC50 of 1.6 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

584.08

Formula

C₂₉H₃₅ClFN₇O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Sunvozertinib
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