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Cat. No.: HY-105529

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Indicine N-oxide

(Synonyms: (+)-Indicine N-oxide; NSC 132319)

Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research.

For research use only. We do not sell to patients.

CAS No.: 41708-76-3
Formula: C₁₅H₂₅NO₆
Molecular Weight:315.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Indicine N-oxide Chemical Structure

CAS No.: 41708-76-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A204	IC₅₀	125 μg/mL Compound: indicine N-oxide	Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay	[PMID: 3210016]
A204	IC₅₀	125 μg/mL Compound: 6 (Indicine N-oxide)	In vitro cytotoxicity against human A204 Rhabdomyosarcoma cell line In vitro cytotoxicity against human A204 Rhabdomyosarcoma cell line	[PMID: 3397989]

Chemical Information

CAS No. 41708-76-3
Molecular Weight 315.36
Formula C₁₅H₂₅NO₆
SMILES

CC(C)[C@]([C@@H](O)C)(O)C(OCC1=CC[N+]2([O-])[C@@]1([H])[C@@H](CC2)O)=O
Synonyms

(+)-Indicine N-oxide; NSC 132319
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. V M Whitehead, et al. Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1990;26(5):377-9. [Content Brief]

[2]. J S Kovach, et al. Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans. Cancer Res. 1979 Nov;39(11):4540-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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