1. Immunology/Inflammation
  2. PGE synthase
  3. Suprofen

Suprofen (Synonyms: TN-762)

Cat. No.: HY-B0270 Purity: 99.44%
Handling Instructions

Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

For research use only. We do not sell to patients.

Suprofen Chemical Structure

Suprofen Chemical Structure

CAS No. : 40828-46-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 336 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

IC50 & Target

PGE synthase[1].

In Vitro

Suprofen (TN-762) is an NSAID. Suprofen (TN-762) is an ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. suprofen was clinically effective but the differential suppression of prostanoids favors 200mg which spares 6-keto PGF1a[1].

Molecular Weight

260.31

Formula

C₁₄H₁₂O₃S

CAS No.

40828-46-4

SMILES

O=C(O)C(C)C1=CC=C(C(C2=CC=CS2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (384.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8416 mL 19.2079 mL 38.4157 mL
5 mM 0.7683 mL 3.8416 mL 7.6831 mL
10 mM 0.3842 mL 1.9208 mL 3.8416 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Suprofen
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