2. Epigenetics
  3. Epigenetic Reader Domain
  4. ZL0590

ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities.

For research use only. We do not sell to patients.

ZL0590 Chemical Structure

ZL0590 Chemical Structure

CAS No. : 2230496-99-6

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 275 In-stock
Solid
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10 mg USD 380 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities[1].

IC50 & Target

IC50: 90 nM (human BRD4 BD1)[1]
Molecular Weight

512.55

Formula

C23H27F3N4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1[C@@H](CCC1)CN2CCOCC2)(C3=CC=C(C=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9510 mL 9.7551 mL 19.5103 mL
5 mM 0.3902 mL 1.9510 mL 3.9021 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9510 mL 9.7551 mL 19.5103 mL 48.7757 mL
5 mM 0.3902 mL 1.9510 mL 3.9021 mL 9.7551 mL
10 mM 0.1951 mL 0.9755 mL 1.9510 mL 4.8776 mL
15 mM 0.1301 mL 0.6503 mL 1.3007 mL 3.2517 mL
20 mM 0.0976 mL 0.4878 mL 0.9755 mL 2.4388 mL
25 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9510 mL
30 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6259 mL
40 mM 0.0488 mL 0.2439 mL 0.4878 mL 1.2194 mL
50 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
60 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8129 mL
80 mM 0.0244 mL 0.1219 mL 0.2439 mL 0.6097 mL
100 mM 0.0195 mL 0.0976 mL 0.1951 mL 0.4878 mL
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ZL0590 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZL05902230496-99-6ZL 0590ZL-0590Epigenetic Reader DomainBRD4 BD1first-in-classnon-KAc binding siteacute airway inflammationInhibitorinhibitorinhibit

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