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Cat. No.: HY-145310

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ZL0590

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Based on 1 Customer Validation

ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC₅₀ of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities. ZL0590 can reduce mucosal inflammation in animal models of inflammatory bowel disease and restores tissue architecture. ZL0590 can be used in research on inflammatory diseases such as inflammatory bowel disease.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 2230496-99-6
Formula: C₂₃H₂₇F₃N₄O₄S
Molecular Weight:512.55

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ZL0590 Chemical Structure

CAS No.: 2230496-99-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 90 nM (human BRD4 BD1)^[1]

All Epigenetic Reader Domain Isoforms :

In Vitro

ZL0590 (Compound 52) has a promising IC₅₀ of 220 nM against CIG5 and IC₅₀ of 370 nM against IL-6 in hSAECs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZL0590 (Compound 52) (10 mg/kg, p.o., 1 day before poly(I:C)) completely inhibits the poly(I:C)-induced neutrophilic inflammation around the small- and medium-sized airways in C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice with poly(I:C) stimulation^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage (p.o.), 1 day before poly(I:C)
Result:

Significantly attenuated inflammatory cytokines (IL-6, MCP-1, and RANTES) in bronchoalveolar lavage fluid as well as inflammatory gene expression (IL-6, KC, ISG54 and CIG5) in lung tissues of mice.
Significantly blocked poly(I:C)-induced H3K122Ac levels in hSAECs and lung tissues of mice.

Chemical Information

CAS No. 2230496-99-6
Appearance Solid
Molecular Weight 512.55
Formula C₂₃H₂₇F₃N₄O₄S
Color White to off-white
SMILES

O=S(N1[C@@H](CCC1)CN2CCOCC2)(C3=CC=C(C=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (195.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9510 mL

9.7551 mL

19.5103 mL

5 mM

0.3902 mL

1.9510 mL

3.9021 mL

10 mM

0.1951 mL

0.9755 mL

1.9510 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408. [Content Brief]

[2]. Yi Li, et al., DEVELOPMENT OF SMALL MOLECULE EPIGENETIC THERAPEUTICS FOR INFLAMMATORY BOWEL DISEASE, 2021 160(3).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9510 mL	9.7551 mL	19.5103 mL	48.7757 mL
	5 mM	0.3902 mL	1.9510 mL	3.9021 mL	9.7551 mL
	10 mM	0.1951 mL	0.9755 mL	1.9510 mL	4.8776 mL
	15 mM	0.1301 mL	0.6503 mL	1.3007 mL	3.2517 mL
	20 mM	0.0976 mL	0.4878 mL	0.9755 mL	2.4388 mL
	25 mM	0.0780 mL	0.3902 mL	0.7804 mL	1.9510 mL
	30 mM	0.0650 mL	0.3252 mL	0.6503 mL	1.6259 mL
	40 mM	0.0488 mL	0.2439 mL	0.4878 mL	1.2194 mL
	50 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9755 mL
	60 mM	0.0325 mL	0.1626 mL	0.3252 mL	0.8129 mL
	80 mM	0.0244 mL	0.1219 mL	0.2439 mL	0.6097 mL
	100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.4878 mL

Keywords

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
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MCE Japan Authorized Agent:

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ZL0590

Bioactive Compound Library Max

Bioactive Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

ZL0590

Bioactive Compound Library Max

Bioactive Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

ZL0590 Related Classifications

HY-145310 Related Classifications