2230496-99-6
Chemical Structure
ZL0590
- CAS No.: 2230496-99-6
- Formula:C23H27F3N4O4S
- Molecular Weight:512.55
IUPAC Name: (S)-1-(4-((2-(morpholinomethyl)pyrrolidin-1-yl)sulfonyl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea
InChIKey: ZPMULUKHFNMJPF-FQEVSTJZSA-N
SMILES: O=S(N1[C@@H](CCC1)CN2CCOCC2)(C3=CC=C(C=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
Biological Activity: ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities. ZL0590 can reduce mucosal inflammation in animal models of inflammatory bowel disease and restores tissue architecture. ZL0590 can be used in research on inflammatory diseases such as inflammatory bowel disease[1][2].
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ZL0590 | 99.86% | ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities. ZL0590 can reduce mucosal inflammation in animal models of inflammatory bowel disease and restores tissue architecture. ZL0590 can be used in research on inflammatory diseases such as inflammatory bowel disease. | ||||||||||||||||||||
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- [1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408. [Content Brief]
- [2]. Yi Li, et al., DEVELOPMENT OF SMALL MOLECULE EPIGENETIC THERAPEUTICS FOR INFLAMMATORY BOWEL DISEASE, 2021 160(3).
Keywords
