1. Anti-infection
    Protein Tyrosine Kinase/RTK
    Apoptosis
    Autophagy
  2. HIV
    FAK
    Apoptosis
    Autophagy
  3. Fangchinoline

Fangchinoline 

Cat. No.: HY-N1372A
Handling Instructions

Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer.

For research use only. We do not sell to patients.

Fangchinoline Chemical Structure

Fangchinoline Chemical Structure

CAS No. : 436-77-1

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Description

Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3].

IC50 & Target

HIV-1 replication[1]; Focal adhesion kinase (FAK)[2]; apoptosis; autophagy[3]

In Vitro

Fangchinoline (2.5-40 µM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 µM (24 h), 12.0 µM (48 h) and 7.57 µM (72 h), and 11.9 µM (24 h), 9.92 µM (48 h) and 7.13 µM (72 h) in 5637 cells[1].
Fangchinoline (5 µM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3[1].

Cell Viability Assay[3]

Cell Line: T24 and 5637 cells
Concentration: 2.5 µM; 5 µM; 10 µM; 20 µM; 30 µM; 40 µM
Incubation Time: 24 hours; 48 hours; 96 hours
Result: Inhibited both T24 and 5637 cells proliferation.

Western Blot Analysis[3]

Cell Line: T24 and 5637 cells
Concentration: 5 µM
Incubation Time: 24 hours
Result: Incresed LC3-II/LC3-I ratio and the cleavage of caspase-3.
Molecular Weight

608.72

Formula

C₃₇H₄₀N₂O₆

CAS No.

436-77-1

SMILES

OC1=C(OC2=CC([[email protected]]3([H])CC(C=C4)=CC=C4O5)=C(CCN3C)C=C2OC)C([[email protected]](N6C)([H])CC7=CC=C(OC)C5=C7)=C(CC6)C=C1OC

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Fangchinoline
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HY-N1372A
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