N,N-Dimethylacetamide
Based on 1 publication(s) in Google Scholar
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 127-19-5
- Formula: C4H9NO
- Molecular Weight:87.12
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Storage:
Store at room temperature 3 years
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N,N-Dimethylacetamide
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Biological Activity
N,N-Dimethylacetamide (10-1000 μM, 24 h) inhibits the bactericidal activity of macrophages in RAW 264.7 cells[1].
N,N-Dimethylacetamide (0.1-10 mM, 2 h) inhibits Aβ-induced inflammation in microglia cell lines SIM-A9 and HMC3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SIM-A9, HMC3
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Concentration:0.1, 1, 10 mM
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Incubation Time:2 h
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Result:Diminished iNOS production.
Decreased Aβ42 in a concentration-dependent manner.
Reduced APP and p-APP protein levels at 1 and 10 mM.
Increased IκBα levels in SIM-A9 cells with both 1 mM and 10 mM and in HMC3 cells with 10 mM.
N,N-Dimethylacetamide (2.1 g/kg/day, intraperitoneally administered) attenuates the clinical and histological features of DSS-induced colitis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-Triggered PTB and Spontaneous Abortions mice[1]
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Dosage:0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
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Administration:i.p. Single dose
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Result:Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
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Animal Model:DSS-induced colitis in C57Bl/6 mice[3]
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Dosage:2.1 g/kg
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Administration:i.p. once a day for four days
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Result:Attenuated inflammation, crypt injury and ulceration.
Chemical Information
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CAS No. 127-19-5
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Appearance Liquid (Density: 0.937 g/cm3)
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Molecular Weight 87.12
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Formula C4H9NO
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Color Colorless to light yellow
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SMILES
CC(N(C)C)=O
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Synonyms
DMAc
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model. [Abstract]2024 Apr 8;14(1):8241. PMID: 38589452
Solvent & Solubility
DMSO : ≥ 100 mg/mL (1147.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30. [Content Brief]
[2]. Wei ZH, et al. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Sci Rep. 2023 May 1;13(1):7077. [Content Brief]
[3]. Koya JB, et al. FDA-Approved Excipient N, N-Dimethylacetamide Attenuates Inflammatory Bowel Disease in In Vitro and In Vivo Models. Fortune J Health Sci. 2022;5:499-509. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 11.4784 mL | 57.3921 mL | 114.7842 mL | 286.9605 mL |
| 5 mM | 2.2957 mL | 11.4784 mL | 22.9568 mL | 57.3921 mL | |
| 10 mM | 1.1478 mL | 5.7392 mL | 11.4784 mL | 28.6961 mL | |
| 15 mM | 0.7652 mL | 3.8261 mL | 7.6523 mL | 19.1307 mL | |
| 20 mM | 0.5739 mL | 2.8696 mL | 5.7392 mL | 14.3480 mL | |
| 25 mM | 0.4591 mL | 2.2957 mL | 4.5914 mL | 11.4784 mL | |
| 30 mM | 0.3826 mL | 1.9131 mL | 3.8261 mL | 9.5654 mL | |
| 40 mM | 0.2870 mL | 1.4348 mL | 2.8696 mL | 7.1740 mL | |
| 50 mM | 0.2296 mL | 1.1478 mL | 2.2957 mL | 5.7392 mL | |
| 60 mM | 0.1913 mL | 0.9565 mL | 1.9131 mL | 4.7827 mL | |
| 80 mM | 0.1435 mL | 0.7174 mL | 1.4348 mL | 3.5870 mL | |
| 100 mM | 0.1148 mL | 0.5739 mL | 1.1478 mL | 2.8696 mL |
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