1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. GW583340 dihydrochloride

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity.

For research use only. We do not sell to patients.

GW583340 dihydrochloride Chemical Structure

GW583340 dihydrochloride Chemical Structure

CAS No. : 1173023-85-2

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Based on 1 publication(s) in Google Scholar

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Description

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity[1][2][3].

In Vitro

GW 583340 dihydrochloride (5 μM) decreases the IC50 values of Mitoxantrone in inhibition of ABCG2-482-R2 and ABCG2-482-T7 cell lines[1].
GW 583340 dihydrochloride (2.5 and 7.5 μM, 24 h) increases in ROS accumulation in both SUM149 and SUM190 cells, and induces cell apoptosis[2].
GW 583340 dihydrochloride (0-10 μM) reduces the colony formation in SCCF1 cells and CatMC cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

671.03

Formula

C28H27Cl3FN5O3S2

CAS No.
SMILES

O=S(CCNCC1=NC(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)=CS1)(C)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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GW583340 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GW583340 dihydrochloride
Cat. No.:
HY-103439
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