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Products are for research use only. Not for human use. We do not sell to patients.
(Tyrphostin AG-1478; AG 1478; NSC 693255; AG1478)
AG-1478 Chemical Structure
|Product name: AG-1478|
|Cat. No.: HY-13524|
AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
IC50 Value: 3 nM 
in vitro: AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein. The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway, were also inhibited by AG1478 . Although AG 1478 inhibited cell growth, DNA synthesis, EGFR tyrosine kinase activity, and receptor autophosphorylation of each cell line in a dose-dependent manner, it was significantly more potent in U87MG. delta EGFR cells than in the other two cell lines .
in vivo: At the lowest dose, plasma drug levels after the cessation of infusion declined with a half-life of approximately 43 min. EGFR activity, measured both by autophosphorylation and downstream signalling, was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG .
|M.Wt||315.75||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO 25 mg/mL; Water <1 mg/mL; Ethanol 13 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||3.1671 mL||15.8353 mL||31.6706 mL|
|5 mM||0.6334 mL||3.1671 mL||6.3341 mL|
|10 mM||0.3167 mL||1.5835 mL||3.1671 mL|
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