Copy Link Print Information

AG490

(Synonyms: Tyrphostin AG490; Tyrphostin B42)
171 Cited Publications
Customer Review

Based on 171 publication(s) in Google Scholar

AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

For research use only. We do not sell to patients.

  • Purity: 99.86%
  • CAS No.: 133550-30-8
  • Formula: C17H14N2O3
  • Molecular Weight:294.30
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • AG490 Chemical Structure
    AG490 Chemical Structure
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
  • Experimental Validation Results for AG490
CAS No.: 133550-30-8
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of AG490:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Protocol
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) AG490

More
Customer Validation & Images
IFWB
  • WB
  • WB
  • WB
  • WB
  • WB
  • WB
  • IF
  • WB
  • WB
  • WB
  • WB

All EGFR Isoforms

More

All STAT Isoforms

More

All JAK Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • AG490 Chemical Structure
    AG490 Chemical Structure
    1/16
  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Jun 13;10(6):465. [Abstract]

    Customer Validation
     pcDNA-AQP3 is used to upregulated AQP3 expression. We found AQP3 overexpression had no influence on STAT3 expression, but could promote STAT3 activation. AG-490 treatment could inhibit STAT3 activation and eliminate the influence of AQP3 overexpression.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2019 Mar 25:232:62-72. [Abstract]

    Customer Validation
     After incubation with AG490 (50 μM), RP (40 μg/mL) or both for 24 h, total protein from SMMC-7721s are analyzed by Western blot.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2019 Nov 1:7:253. [Abstract]

    Customer Validation
     STAT3 regulates miR-384 transcription. CD4C naïve T cells are cultured with IL-6, siRNA, or AG490, and then p-STAT3 and STAT3 levels are tested by Western blot.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2019 Mar;12(3):485-492. [Abstract]

    Customer Validation
     AG490 blocks the IL6/STAT3/PD-L1 signaling pathway and is more pronounced after knockdown of IDO1. T24 and UMUC3 cells after IDO1 knockdown are treated with STAT3 specific inhibitor AG490. The protein levels of STAT3, P-STAT3, and PD-L1 are measured by Western blot analysis.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2019 Jun;26(6):829-838. [Abstract]

    Customer Validation
     The protein expression levels of p-JAK2, JAK2, p-STAT3, and STAT3 are detected by Western blot with the treatment of ,MSA, AG490 or MSA+AG490.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 29;9(9):867. [Abstract]

    Customer Validation
     AG490 decreases c-Met expression in MGC803 and AGS cells when they are co-cultured with CAFs.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Nov 7;66(44):11757-11766. [Abstract]

    Customer Validation
     The number of GFP-LC3 dots are reduced significantly after inhibiting STAT3 (AG-490) signaling.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Reprod Biol Endocrinol. 2018 May 31;16(1):55. [Abstract]

    Customer Validation
     Western blot analysis of claudin 5, occludin and ZO-1 in TM4 cells, cells are treated with 100 nM Leptin or pre-treated with different inhibitors following a 100 nM Leptin treatment.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Jun;17(6):7595-7602. [Abstract]

    Customer Validation
     Representative images show the expression levels of α SMA, calponin and osteopontin (OPN) protein.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Oncogene. 2017 May 25;36(21):2946-2956. [Abstract]

    Customer Validation
     (a) Immunoblotting analysis of pSTAT3, CITED4, and CCND1 in CL1-5 cells treated with AG490 (5 μM) for the indicated times. α-Tubulin is assessed as an internal control. (b) Q-PCR analysis of CITED4 in A549 cells treated with AG490 (5 μM) for the indicated times.

  • 1/16

    AG490 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Dec;16(6):9309-9316. [Abstract]

    Customer Validation
     Ad IL 23 intensifies the high expression levels of IL 17A, TNF α and IL 6 induced by myocardial I/R, which is inhibited by AG490. Levels of IL 17A in myocardial tissues from infarct and risk regions (n=6). The addition of AG490 significantly inhibits the effect of Ad IL 23.

  • AG490