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製品番号: HY-144368

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CO delivery molecule 1

CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release.

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CAS 番号: 1972616-04-8
分子式: C₂₃H₂₁NO₃
分子量:359.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CO delivery molecule 1 構造式

CAS 番号: 1972616-04-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TNF Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: 4	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay	[PMID: 35178180]
A549	IC₅₀	10.7 μM Compound: 4	Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay	[PMID: 35178180]
RAW264.7	IC₅₀	67.2 μM Compound: 4	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay	[PMID: 35178180]

化学情報

CAS 番号 1972616-04-8
分子量 359.42
分子式 C₂₃H₂₁NO₃
SMILES

O=C1C2=CC3=CC=CC=C3C=C2OC(C4=CC=C(N(CC)CC)C=C4)=C1O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lazarus LS, et al. Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization. ACS Med Chem Lett. 2022;13(2):236-242. Published 2022 Feb 1. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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