CO delivery molecule 1
CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release.
For research use only. We do not sell to patients.
- CAS No.: 1972616-04-8
- Formula: C23H21NO3
- Molecular Weight:359.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 4
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
|
[PMID: 35178180] |
| A549 | IC50 |
10.7 μM
Compound: 4
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Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay
|
[PMID: 35178180] |
| RAW264.7 | IC50 |
67.2 μM
Compound: 4
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
|
[PMID: 35178180] |
Chemical Information
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CAS No. 1972616-04-8
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Molecular Weight 359.42
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Formula C23H21NO3
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SMILES
O=C1C2=CC3=CC=CC=C3C=C2OC(C4=CC=C(N(CC)CC)C=C4)=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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