1. NF-κB
  2. Keap1-Nrf2
    NF-κB
  3. CDDO-dhTFEA

CDDO-dhTFEA (Synonyms: RTA dh404)

Cat. No.: HY-112671
Handling Instructions

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

For research use only. We do not sell to patients.

CDDO-dhTFEA Chemical Structure

CDDO-dhTFEA Chemical Structure

CAS No. : 1191265-33-4

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Description

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].

IC50 & Target

Nrf2

 

NF-κB

 

Molecular Weight

574.72

Formula

C₃₃H₄₅F₃N₂O₃

CAS No.

1191265-33-4

SMILES

CC(C)([[email protected]](CC[[email protected]@]([[email protected]@]1(CC[[email protected]]2(CCC(C)(C[[email protected]]2([[email protected]]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[[email protected]]5(C)[[email protected]@]4([H])CC3=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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CDDO-dhTFEA
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HY-112671
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