1. NF-κB
  2. Keap1-Nrf2
    NF-κB
  3. CDDO-dhTFEA

CDDO-dhTFEA (Synonyms: RTA dh404)

Cat. No.: HY-112671 Purity: 99.71%
Handling Instructions

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

For research use only. We do not sell to patients.

CDDO-dhTFEA Chemical Structure

CDDO-dhTFEA Chemical Structure

CAS No. : 1191265-33-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 240 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 325 In-stock
Estimated Time of Arrival: December 31
25 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 970 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Description

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].

IC50 & Target[1]

Nrf2

 

NF-κB

 

Molecular Weight

574.72

Formula

C₃₃H₄₅F₃N₂O₃

CAS No.

1191265-33-4

SMILES

CC(C)([[email protected]](CC[[email protected]@]([[email protected]@]1(CC[[email protected]]2(CCC(C)(C[[email protected]]2([[email protected]]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[[email protected]]5(C)[[email protected]@]4([H])CC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (452.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7400 mL 8.6999 mL 17.3998 mL
5 mM 0.3480 mL 1.7400 mL 3.4800 mL
10 mM 0.1740 mL 0.8700 mL 1.7400 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CDDO-dhTFEARTA dh404RTA dh 404RTA dh-404Keap1-Nrf2NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Product name:
CDDO-dhTFEA
Cat. No.:
HY-112671
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