2. NF-κB
  3. Keap1-Nrf2
    NF-κB
  4. CDDO-dhTFEA

CDDO-dhTFEA  (Synonyms: RTA dh404)

Cat. No.: HY-112671 Purity: 99.71%
COA Handling Instructions

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

For research use only. We do not sell to patients.

CDDO-dhTFEA Chemical Structure

CDDO-dhTFEA Chemical Structure

CAS No. : 1191265-33-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 240 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 240 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 325 In-stock
Estimated Time of Arrival: December 31
25 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 970 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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  • Customer Review

Description

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].

IC50 & Target[1]

Nrf2

 

NF-κB

 

Molecular Weight

574.72

Appearance

Solid

Formula

C33H45F3N2O3
CAS No.
SMILES

CC(C)([[email protected]](CC[[email protected]@]([[email protected]@]1(CC[[email protected]]2(CCC(C)(C[[email protected]]2([[email protected]]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[[email protected]]5(C)[[email protected]@]4([H])CC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7400 mL 8.6999 mL 17.3998 mL
5 mM 0.3480 mL 1.7400 mL 3.4800 mL
10 mM 0.1740 mL 0.8700 mL 1.7400 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.72 mg/mL (2.99 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.71%

COA (250 KB) HNMR (205 KB) LCMS (120 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CDDO-dhTFEA1191265-33-4RTA dh404RTA dh 404RTA dh-404Keap1-Nrf2NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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