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Homosalate  (Synonyms: Homomenthyl salicylate)

Cat. No.: HY-B0928 Purity: ≥95.0%
COA Handling Instructions

Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity.

For research use only. We do not sell to patients.

Homosalate Chemical Structure

Homosalate Chemical Structure

CAS No. : 118-56-9

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Liquid
100 mg USD 60 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Homosalate:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Homosalate

WB

    Homosalate purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2018 Sep 21;243(Pt B):1263-1273.  [Abstract]

    The expression of GRP78, IRE1α, p-eIF2α, t-eIF2α, and TUBA are analyzed in response to homosalate in a dose-dependent manner (0, 50, 100, and 200 µM) for 12 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity[1][2][3].

    In Vitro

    Homosalate (250-2000 μM, 24 h) has cytotoxic and genotoxic effects on MCF-7 cells[1].
    Homosalate (10 μM) can promote the release of tumor-derived extracellular vesicles and has a protective effect against loss of anchoring[2].
    Homosalate (20-100 μM, 2 h) significantly inhibits HTR8/Svneo cell invasion through PI3K/AKT and MAPK pathways[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MCF-7
    Concentration: 250, 500, 750, 1000, 1500, 2000 μM
    Incubation Time: 24 h
    Result: Induced micronucleus formation at 750 and 1000 µM.
    Decreased cell viability up to 57% at 2000 μM.

    Apoptosis Analysis[3]

    Cell Line: HTR8/SVneo
    Concentration: 0, 20, 50 100 μM
    Incubation Time: 2 h
    Result: Reduced proliferation and increased apoptotic cell ratio.

    Western Blot Analysis[3]

    Cell Line: HTR8/SVneo
    Concentration: 0, 20, 50 100 μM
    Incubation Time: 2 h
    Result: Increased the phosphorylation of ERK1/2 (p-ERK1/2) and P38 (p-P38).
    Molecular Weight

    262.34

    Formula

    C16H22O3

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    O=C(OC1CC(C)(C)CC(C)C1)C2=CC=CC=C2O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (381.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8118 mL 19.0592 mL 38.1185 mL
    5 mM 0.7624 mL 3.8118 mL 7.6237 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (9.53 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (9.53 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.8118 mL 19.0592 mL 38.1185 mL 95.2962 mL
    5 mM 0.7624 mL 3.8118 mL 7.6237 mL 19.0592 mL
    10 mM 0.3812 mL 1.9059 mL 3.8118 mL 9.5296 mL
    15 mM 0.2541 mL 1.2706 mL 2.5412 mL 6.3531 mL
    20 mM 0.1906 mL 0.9530 mL 1.9059 mL 4.7648 mL
    25 mM 0.1525 mL 0.7624 mL 1.5247 mL 3.8118 mL
    30 mM 0.1271 mL 0.6353 mL 1.2706 mL 3.1765 mL
    40 mM 0.0953 mL 0.4765 mL 0.9530 mL 2.3824 mL
    50 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9059 mL
    60 mM 0.0635 mL 0.3177 mL 0.6353 mL 1.5883 mL
    80 mM 0.0476 mL 0.2382 mL 0.4765 mL 1.1912 mL
    100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.9530 mL
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    Homosalate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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