Homosalate
Based on 1 publication(s) in Google Scholar
Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 118-56-9
- Formula: C16H22O3
- Molecular Weight:262.34
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Homosalate
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Customer Validation & Images
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WB
Biological Activity
Homosalate (250-2000 μM, 24 h) has cytotoxic and genotoxic effects on MCF-7 cells[1].
Homosalate (10 μM) can promote the release of tumor-derived extracellular vesicles and has a protective effect against loss of anchoring[2].
Homosalate (20-100 μM, 2 h) significantly inhibits HTR8/Svneo cell invasion through PI3K/AKT and MAPK pathways[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7
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Concentration:250, 500, 750, 1000, 1500, 2000 μM
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Incubation Time:24 h
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Result:Induced micronucleus formation at 750 and 1000 µM.
Decreased cell viability up to 57% at 2000 μM.
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Cell Line:HTR8/SVneo
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Concentration:0, 20, 50 100 μM
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Incubation Time:2 h
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Result:Reduced proliferation and increased apoptotic cell ratio.
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Cell Line:HTR8/SVneo
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Concentration:0, 20, 50 100 μM
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Incubation Time:2 h
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Result:Increased the phosphorylation of ERK1/2 (p-ERK1/2) and P38 (p-P38).
Chemical Information
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CAS No. 118-56-9
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Appearance Liquid (Density: 1.05 g/cm3)
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Molecular Weight 262.34
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Formula C16H22O3
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Color Colorless to light yellow
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SMILES
O=C(OC1CC(C)(C)CC(C)C1)C2=CC=CC=C2O
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Synonyms
Homomenthyl salicylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Environ Pollut
Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. [Abstract]2018 Dec;243(Pt B):1263-1273. PMID: 30267922
Homosalate purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2018 Dec;243(Pt B):1263-1273. [Abstract]
The expression of GRP78, IRE1α, p-eIF2α, t-eIF2α, and TUBA are analyzed in response to homosalate in a dose-dependent manner (0, 50, 100, and 200 µM) for 12 h.
Solvent & Solubility
DMSO : 100 mg/mL (381.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.53 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.53 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Yazar S, et al. Assessment of the cytotoxicity and genotoxicity of homosalate in MCF-7. J Cosmet Dermatol. 2020 Jan;19(1):246-252. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
[3]. Yang C, et al. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. Environ Pollut. 2018 Dec;243(Pt B):1263-1273. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.8118 mL | 19.0592 mL | 38.1185 mL | 95.2962 mL |
| 5 mM | 0.7624 mL | 3.8118 mL | 7.6237 mL | 19.0592 mL | |
| 10 mM | 0.3812 mL | 1.9059 mL | 3.8118 mL | 9.5296 mL | |
| 15 mM | 0.2541 mL | 1.2706 mL | 2.5412 mL | 6.3531 mL | |
| 20 mM | 0.1906 mL | 0.9530 mL | 1.9059 mL | 4.7648 mL | |
| 25 mM | 0.1525 mL | 0.7624 mL | 1.5247 mL | 3.8118 mL | |
| 30 mM | 0.1271 mL | 0.6353 mL | 1.2706 mL | 3.1765 mL | |
| 40 mM | 0.0953 mL | 0.4765 mL | 0.9530 mL | 2.3824 mL | |
| 50 mM | 0.0762 mL | 0.3812 mL | 0.7624 mL | 1.9059 mL | |
| 60 mM | 0.0635 mL | 0.3177 mL | 0.6353 mL | 1.5883 mL | |
| 80 mM | 0.0476 mL | 0.2382 mL | 0.4765 mL | 1.1912 mL | |
| 100 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.9530 mL |
Homosalate Related Classifications
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