1. Cell Cycle/DNA Damage
    Epigenetics
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. PARP
    Reactive Oxygen Species
    Aryl Hydrocarbon Receptor
  3. 3',4'-Dimethoxyflavone

3',4'-Dimethoxyflavone 

Cat. No.: HY-N8572 Purity: 98.76%
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3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects.

For research use only. We do not sell to patients.

3',4'-Dimethoxyflavone Chemical Structure

3',4'-Dimethoxyflavone Chemical Structure

CAS No. : 4143-62-8

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Based on 1 publication(s) in Google Scholar

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Description

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].

IC50 & Target

PARP, Aryl hydrocarbon receptor[1]

In Vitro

3',4'-Dimethoxyflavone (10 and 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine (MNNG) (HY-128612)[2].
3',4'-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells[2].
3',4'-Dimethoxyflavone (12.5, 25, 50 and 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551)[2].
3',4'-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 and T47D cells[3].
3',4'-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction and AhR-mediated inhibition of estrogen-induced gene expression in T47D and MCF-7 breast cancer cells[3].
3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Primary cortical neurones (isolated from fetal CD1 mice, incubated with NMDA)
Concentration: 12.5, 25, 50 and 100 μM
Incubation Time: 15-20 h
Result: Reduced concentration-dependently neuronal death induced by exposure to NMDA.

Cell Proliferation Assay[4]

Cell Line: CD34+ cells
Concentration: 2.5 μM
Incubation Time: 7 days
Result: Induced a significantly higher amplification of the CD34+ population under normoxia.
Molecular Weight

282.29

Formula

C17H14O4

CAS No.
SMILES

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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3',4'-Dimethoxyflavone
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