1. NF-κB
    Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Keap1-Nrf2
    Reactive Oxygen Species
  3. Dehydrocurdione

Dehydrocurdione 

Cat. No.: HY-N8160
Handling Instructions

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Dehydrocurdione Chemical Structure

Dehydrocurdione Chemical Structure

CAS No. : 38230-32-9

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Description

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].

In Vitro

Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM[1].
Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: RAW 264.7 cells
Concentration: 100 μM
Incubation Time: 24 hours
Result: Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr.
In Vivo

Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis[2].
Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[2]
Dosage: 120 mg/kg
Administration: P.o ; daily for 12 days
Result: Significantly reduces chronic adjuvant arthritis.
Molecular Weight

234.33

Formula

C₁₅H₂₂O₂

CAS No.
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Dehydrocurdione
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