Dehydrocurdione

Cat. No.: HY-N8160 Purity: 97%: Data Sheet
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Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Dehydrocurdione Chemical Structure

CAS No. : 38230-32-9

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5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Ca-Ski	IC₅₀	21.7 g/mL Compound: 2	Cytotoxicity against human CaSki cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human CaSki cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
HT-29	IC₅₀	22.7 g/mL Compound: 2	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
HUVEC	IC₅₀	24 g/mL Compound: 2	Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
KG-1a	IC₅₀	> 100 μg/mL Compound: 2	Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
MCF7	IC₅₀	33 g/mL Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
MOLT-4	IC₅₀	35 μg/mL Compound: 2	Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
MOLT-4	IC₅₀	> 100 μg/mL Compound: 2	Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
PC-3	IC₅₀	19.1 g/mL Compound: 2	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]

In Vitro

Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM^[1].
Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	RAW 264.7 cells
Concentration:	100 μM
Incubation Time:	24 hours
Result:	Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr.

In Vivo

Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis^[2].
Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats^[2]
Dosage:	120 mg/kg
Administration:	P.o ; daily for 12 days
Result:	Significantly reduces chronic adjuvant arthritis.

Molecular Weight

234.33

Formula

C₁₅H₂₂O₂

CAS No.

38230-32-9

Appearance

Liquid

Color

Colorless to light yellow

SMILES

C/C(C)=C(CC1=O)/C(C/C(C)=C/CC[C@@H]1C)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 97%

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Data Sheet (293 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897. [Content Brief]

[2]. Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481. [Content Brief]