38230-32-9
38230-32-9
Chemical Structure
Dehydrocurdione
- CAS. Nr.: 38230-32-9
- Formula:C15H22O2
- Molecular Weight:234.33
IUPAC Name: (S,E)-6,10-dimethyl-3-(propan-2-ylidene)cyclodec-6-ene-1,4-dione
InChIKey: ZYPUZCWWTYIGFV-BCMYLCSRSA-N
SMILES: C/C(C)=C(CC1=O)/C(C/C(C)=C/CC[C@@H]1C)=O
Biological Activity: Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].
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Dehydrocurdione | Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity. | |||||||||||||||||||||
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References
- [1]. Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897. [Content Brief]
- [2]. Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481. [Content Brief]
