1. Immunology/Inflammation
  2. COX
  3. Vedaprofen

Vedaprofen  (Synonyms: Quadrisol; CERM 10202; PM 150)

Cat. No.: HY-118827 Purity: 99.81%
COA Handling Instructions

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM.

For research use only. We do not sell to patients.

Vedaprofen Chemical Structure

Vedaprofen Chemical Structure

CAS No. : 71109-09-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 326 In-stock
Solution
10 mM * 1 mL in DMSO USD 326 In-stock
Solid
1 mg USD 105 In-stock
5 mg USD 140 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 760 In-stock
100 mg USD 1200 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Vedaprofen:

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

IC50 & Target

COX-1

 

In Vitro

Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9±5 and 630±148 ng/mL, respectively[1]. Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency[2]. Vedaprofen shows high E. coli SC binding affinity (Ki=131 μM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic parameters of vedaprofen in dogs[3].

Intravenous dose (mg/kg) t1/2β (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL)
0.5 16.8±2.2 8612±1135 9518±1223

Oral dose (mg/kg) t1/2β (h) Cmax (ng/mL) tmax (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL) F0–∞ (%)
0.5 12.7±2.1 2739±277 0.63±0.14 7090±1311 7650±1348 86±7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.38

Formula

C19H22O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(C2CCCCC2)C3=C1C=CC=C3)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (177.07 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5413 mL 17.7066 mL 35.4133 mL
5 mM 0.7083 mL 3.5413 mL 7.0827 mL
10 mM 0.3541 mL 1.7707 mL 3.5413 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Vedaprofen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vedaprofen
Cat. No.:
HY-118827
Quantity:
MCE Japan Authorized Agent: