1. Immunology/Inflammation
  2. COX
  3. Vedaprofen

Vedaprofen (Synonyms: Quadrisol; CERM 10202; PM 150)

Cat. No.: HY-118827
Handling Instructions

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM.

For research use only. We do not sell to patients.

Vedaprofen Chemical Structure

Vedaprofen Chemical Structure

CAS No. : 71109-09-6

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Vedaprofen:

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

IC50 & Target

COX-1

 

In Vitro

Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9±5 and 630±148 ng/mL, respectively[1]. Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency[2]. Vedaprofen shows high E. coli SC binding affinity (Ki=131 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic parameters of vedaprofen in dogs[3].

Intravenous dose (mg/kg) t1/2β (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL)
0.5 16.8±2.2 8612±1135 9518±1223

Oral dose (mg/kg) t1/2β (h) Cmax (ng/mL) tmax (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL) F0–∞ (%)
0.5 12.7±2.1 2739±277 0.63±0.14 7090±1311 7650±1348 86±7

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.38

Formula

C19H22O2

CAS No.
SMILES

CC(C1=CC=C(C2CCCCC2)C3=C1C=CC=C3)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vedaprofen
Cat. No.:
HY-118827
Quantity:
MCE Japan Authorized Agent: