71109-09-6
71109-09-6
Chemical Structure
Vedaprofen
Synonym(s): Quadrisol; CERM 10202; PM 150
- CAS No.: 71109-09-6
- Formula:C19H22O2
- Molecular Weight:282.38
IUPAC Name: 2-(4-cyclohexylnaphthalen-1-yl)propanoic acid
InChIKey: VZUGVMQFWFVFBX-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C2CCCCC2)C3=C1C=CC=C3)C(O)=O
Biological Activity: Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].
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Vedaprofen | 98.73% | Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM. | ||||||||||||||||||||
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Vedaprofen (Standard) | ≥98% | Vedaprofen (Standard) is the analytical standard of Vedaprofen. This product is intended for research and analytical applications. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM. | ||||||||||||||||||||
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Vedaprofen-d3 | Vedaprofen-d3 is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM. | |||||||||||||||||||||
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References
- [1]. P Lees, et al. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. [Content Brief]
- [2]. Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487. [Content Brief]
