Anti-inflammatory agent 67
Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC50s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII).
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- Formule: C11H11N3O6S2
- Masse moléculaire:345.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
10.4 μM (COX-1), 50 nM (COX-2)[1]
Ki: 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), 13.3 nM (CA XII)[1]
Chemical Information
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Masse moléculaire 345.35
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Formule C11H11N3O6S2
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SMILES
O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Badawi WA, et al. Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 67 Related Classifications
HY-163116 Related Classifications
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