Anti-inflammatory agent 67
Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC50s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C11H11N3O6S2
- 분자량:345.35
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
10.4 μM (COX-1), 50 nM (COX-2)[1]
Ki: 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), 13.3 nM (CA XII)[1]
Chemical Information
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분자량 345.35
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화학식 C11H11N3O6S2
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SMILES
O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Badawi WA, et al. Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 67 Related Classifications
HY-163116 Related Classifications
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