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Chloroquine dihydrochloride

1304 Cited Publications
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Based on 1304 publication(s) in Google Scholar

Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).

For research use only. We do not sell to patients.

  • Purity: 99.61%
  • CAS No.: 3545-67-3
  • Formula: C18H28Cl3N3
  • Molecular Weight:392.79
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Chloroquine dihydrochloride Chemical Structure
    Chloroquine dihydrochloride Chemical Structure
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
  • Experimental Validation Results for Chloroquine dihydrochloride
CAS No.: 3545-67-3
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  • Chloroquine dihydrochloride Chemical Structure
    Chloroquine dihydrochloride Chemical Structure
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  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Apr 29;23(1):86. [Abstract]

    Customer Validation
     293 cells transfected with the indicated vectors were treated with chloroquine (20 μM) or DMSO for 6 h. Cell lysates were prepared, and the CDC6 protein level was measured by Western blotting.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2024 Jul;13(7):e12468. [Abstract]

    Customer Validation
     Western blotting showing the protein degradation of HEXB by using Chloroquine (CQ) (10 μM, 24 h).

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Sep 10;18(36):24872-24897. [Abstract]

    Customer Validation
     ​Chloroquine (50 nM, 24 h), as an autophagy inhibitor, blocks autophagosomal-lysosomal fusion in HT22 cells, leading to impaired autophagic flux.​

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jan 30;18(4):3733-3751. [Abstract]

    Customer Validation
     The protein levels of SOX2 in 100 μg/mL of PS-NP-exposed Swan 71 cells treated with CHX (10 μg/mL; 4 h) and MG132 (10 μM; 6 h) or chloroquine (CQ) (15 μM; 6 h).

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Dec;33(12):904-922. [Abstract]

    Customer Validation
     A375 cells were pretreated with CQ (30μM) or MG132 (100 nM) for 2 hours, and then treated with CCCP/FeSO4 plus mannose for 24 hours. Tubulin was used to determine the amount of loading proteins.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 May;43(5):582-612. [Abstract]

    Customer Validation
     WB analysis of LC3 and p62 expression in MCF7 and SKBR3 cells after YAP1 transient overexpression for 48 h with or without EBSS (6 h) starvation or CQ (Chloroquine) (20 µmol/L, 6 h) treatment.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2023 Jul;12(7):e12342. [Abstract]

    Customer Validation
     The sEV cocultured 22Rv1 cells were pretreated with 1μM CQ and followed by IR treatment. The cell survival rate was determined using colony survival assay (n = 3).

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2023 Jul;12(7):e12342. [Abstract]

    Customer Validation
     After pretreating cells with 10μM CQ, the levels of phospho‐AMPKα and autophagic markers in the cells were quantified by immunoblotting using the specific antibodies. β‐actin serves as a loading control.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Nov 28;17(22):22240-22258. [Abstract]

    Customer Validation
     Sorafenib-sensitive HepG2 cells, with or without URB1-AS1 overexpression, were treated with the lysosomal inhibitor chloroquine or vehicle for 24 h. Ferritin H levels were analyzed by Western blot.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Immun Inflamm Dis. 2023 Apr;11(4):e830. [Abstract]

    Customer Validation
     Chloroquine (10 μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of LC3 in BMDCs.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Immun Inflamm Dis. 2023 Apr;11(4):e830. [Abstract]

    Customer Validation
     Chloroquine (10 μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of Beclin1 and LC3II/I while increasing the expression of P62 in BMDCs.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Prostate. 2019 Jan;79(1):44-53. [Abstract]

    Customer Validation
     Treatment with sub-dose of Everolimus (10 nM), together with CQ (5 µM) increases the levels of Bax and cleaved PARP, and decreases the levels of Bcl-2 expression in both PC3 and LNPER cells.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2018 May;37(22):2936-2952. [Abstract]

    Customer Validation
     IPZ-treated U87 and U251 cells are treated with or without Baf-A1 (5 nM), CQ (40 μM), or MG132 (1 μM) for 48 h, followed by western blots.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     MC3T3-E1 cells are treated with AICAR (10 μM) in the presence or absence of 3-MA (5 mM) or CQ (10 μM) for 24 h, after which western blot analysis is conducted.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Mar 7;8(1):4108. [Abstract]

    Customer Validation
     L02 cells exposed to PA (200 μM) with different concentrations of Rapamycin (Rapa) or Chloroquine (CQ) for 24 h. Palmitate (PA) induced higher protein expression of LC3 II/I and p62 compared with control as indicated by western blot.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]

    Customer Validation
     Raw264.7 macrophages treated without or with Rapamycin (1 μΜ) or Chloroquine (20 μΜ) for 48 h. Western blot shows the protein expression levels of Atg5, Beclin1, LC3, and p62/SQSMT1.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: J Pharmacol Exp Ther. 2018 Oct;367(1):20-27. [Abstract]

    Customer Validation
     Protein expression of LC3B and p62 in Panc-1 cells treated with Carboxamidotriazole (CAI) and/or Chloroquine (CQ).

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):501-507. [Abstract]

    Customer Validation
     Western blot analysis of autophagy markers and LAMP2 in mice with AAV-vaspin and Chloroquine (CQ) pretreatment after I/R (1d).

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;48(6):2318-2336. [Abstract]

    Customer Validation
     Cells are treated with Rapamycin (Rp; 10 μM)+Eicosapentaenoic acid (EPA; 40 μM) with or without Chloroquine (CQ; 5 μM) for 48 h. Cell extracts are prepared and subjected to western blot analysis.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Aug 24:682:112-117. [Abstract]

    Customer Validation
     After treatment of CDDP with or without the autophagy inhibitor CQ, the expression of LC3-II in the CQ+CDDP group is less than that in the CQ group but is higher than that in the CDDP group at 24 h and 96 h.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1617-1627. [Abstract]

    Customer Validation
     GFP-LC3B-expressing LX-2 cells are treated with DMSO, 3-MA (10 mM), or Chloroquine (30 μM) alone or in the presence of Carvedilol (CVD, 10 μM) for 24 h. The conversion of LC3B-I to LC3B-II is evaluated using immunoblotting.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2017 May:19:49-59. [Abstract]

    Customer Validation
     mCherry-GFPLC3 puncta analysis in SPC-A-1 cells. Cells are transfected with mCherry-GFP-LC3 plasmid and incubated for 6 h. Next, cells are pretreated with or without Chloroquine (50 μM) for 1 h followed by stimulation of 5 μM Flu for 24 h or 36 h. Scale bar, 10 μm and 2 μm (magnified graph). The lysosomal inhibitor Chloroquine (CQ) raises the lysosomal pH and increases the autophagic flux.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Jun 7;7(1):2929. [Abstract]

    Customer Validation
     p53 and Cell apoptosis. MCF7 and MDA-MB-231 cells are treated with 80 μM ω-3 FFAs, 20 μM ATRA alone or in combination for 48 h. The expression of PARP and p53 protein. β-Actin is used as an internal control.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150. [Abstract]

    Customer Validation
     Cells are treated with RA (20 μM) plus ω-3 PUFAs (80 μM) with or without CQ (5 μM) for 24 h. Cell extracts are prepared and subjected to western blotting analysis.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1075-1084. [Abstract]

    Customer Validation
     The change of LC3 is analyzed by western blotting after 6 h hypoxia in the presence or absence of Chloroquine of WDR26-overexpressing H9c2 cells.

  • 1/16

    Chloroquine dihydrochloride purchased from MedChemExpress. Usage Cited in: Tumour Biol. 2016 Jul;37(7):8811-24. [Abstract]

    Customer Validation
     Assays for autophagy activity. Immunoblot analysis for LC3B. Compared with the Lenti-NC cells, the Lenti-CD44v6 cells display a higher intensity of autophagy flux but not steady-state levels when treated with 5-FU (*P<0.001).

  • Chloroquine dihydrochloride