1. Academic Validation
  2. Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization

Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization

  • Sci Rep. 2026 Mar 31. doi: 10.1038/s41598-026-45925-z.
Xuan Zhu # 1 2 Yuhan Zhou # 3 Mingyu Ruan # 3 Xuebin Yang 4 5 Gang Pei # 6 7 Jin Tan # 8
Affiliations

Affiliations

  • 1 Department of Science and Technology, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 2 Department of Stomatology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410021, China.
  • 3 School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 4 College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 5 Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha, 410208, China.
  • 6 College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. [email protected].
  • 7 Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha, 410208, China. [email protected].
  • 8 Department of Stomatology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410021, China. [email protected].
  • # Contributed equally.
Keywords

Liver fibrosis; Macrophage; Oral submucous fibrosis; Pomolic acid; Pro-fibrotic macrophage polarization; β-arrestin 2.

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