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4-Octyl itaconate

(Synonyms: 4-OI)
94 Cited Publications
Customer Review

Based on 94 publication(s) in Google Scholar

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

For research use only. We do not sell to patients.

  • Purity: 99.92%
  • CAS No.: 3133-16-2
  • Formula: C13H22O4
  • Molecular Weight:242.31
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 4-Octyl itaconate Chemical Structure
    4-Octyl itaconate Chemical Structure
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
  • Experimental Validation Results for 4-Octyl itaconate
CAS No.: 3133-16-2
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  • 4-Octyl itaconate Chemical Structure
    4-Octyl itaconate Chemical Structure
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  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Feb 28;42(3):112145. [Abstract]

    Customer Validation
     4-Octyl Itaconate (4-OI; 250 µM; 2 h) significantly inhibits the phosphorylation of STING and the activation of downstream signaling molecules in RAW264.7 macrophages.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2022 May 31;14(1):27. [Abstract]

    Customer Validation
     Hematoxylin and eosin (H&E) staining indicated 4-octyl itaconate (4-OI) (50 mg/kg; injected locally; daily for 14 days ) could play a pivotal role in decreasing alveolar bone loss in experimental periodontitis models.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2022 May 31;14(1):27. [Abstract]

    Customer Validation
     4-octyl itaconate (4-OI; 200 μM) induces a shift in polarization phenotype of macrophages in vitro. Expression of M1 and M2-related genes in RAW 264.7 using qRT-PCR (The M1-related IL-1β, IL-6, CCL2, iNOS, CD86, and the M2-related TGF-β, Arg-1 and CD206).

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2022 May 31;14(1):27. [Abstract]

    Customer Validation
     4-octyl itaconate (4-OI; 200 μM) induces a shift in polarization phenotype of macrophages in vitro. Micrographs showing staining of iNOS, CD86 and CD206 obtained using confocal laser scanning microscopy.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2022 May 31;14(1):27. [Abstract]

    Customer Validation
     The role of Nrf2 exerted in the protection of 4-octyl itaconate (4-OI; 200 μM) against periodontal inflammation. a The Nrf2 protein expression in nuclei fraction lysates quantified by Western blotting. The expression of Nrf2 downstream ARE-dependent proteins in RAW264.7 measured by Western blotting.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2022 Oct 24;18(16):6189-6209. [Abstract]

    Customer Validation
     Western blotting confirmes that TNF-α, IL-1β, and IFN-γ expression are significantly higher in RAW264.7 cells treated with LPS and are significantly inhibited by OI (4-Octyl Itaconate) (62.5, 125 µM; 12 h).

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Feb 10;13(2):140. [Abstract]

    Customer Validation
     Cell Counting Kit-8 (CCK-8) results for microglia treated with different concentrations of 4-Octyl Itaconate (4-OI) for 24 and 48 h.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Feb 10;13(2):140. [Abstract]

    Customer Validation
     Evaluated the effect of 4-Octyl Itaconate (4-OI; 20-80 μM) on the LPS-induced inflammation model. The mRNA expression of iNOS, COX2 and IL-6 are measured by qRT-PCR.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Feb 10;13(2):140. [Abstract]

    Customer Validation
     Evaluated the effect of 4-Octyl Itaconate (4-OI; 20-80 μM) on the LPS-induced inflammation model. The protein expression of iNOS, COX2 and IL-6 are measured by western blot.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Feb 10;13(2):140. [Abstract]

    Customer Validation
     After 48 h of co-cultivation with 4-Octyl Itaconate (4-OI; 80 μM)-treated microglia, the proportion of apoptotic PC12 cells decreased significantly, the expression of Cleave-caspase3 decreased, and the expression of Bcl2 increased.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Aug 1;188:404-418. [Abstract]

    Customer Validation
     CCK-8 assay of the viability of valve interstitial cells treated with different concentrations of 4-Octyl Itaconate (OI) for 24 h.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Aug 1;188:404-418. [Abstract]

    Customer Validation
     Representative images showing immunofluorescent staining of Nrf2 (red) after valve interstitial cells are treated with 40 μM 4-Octyl Itaconate (OI) for 2 h.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Aug 1;188:404-418. [Abstract]

    Customer Validation
     Relative quantification of the mRNA expression of Nrf2, Hmox1 and NQO1 after valve interstitial cells are treated with different concentrations of 4-Octyl Itaconate (OI) for 4 h.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Aug 1;188:404-418. [Abstract]

    Customer Validation
     Representative Western blot images and quantification of Hmox1 and NQO1 protein expression after valve interstitial cells are treated with different concentrations of 4-Octyl Itaconate (OI) for 24 h.

  • 1/16

    4-Octyl itaconate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 May 25;12:651444. [Abstract]

    Customer Validation
     Nrf2 knockdown attenuates the protective effect of 4-Octyl Itaconate (OI) in CCl4-treated NCTC 1469 cells.

  • 4-Octyl itaconate