Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization

  • Sci Rep. 2026 Mar 31. doi: 10.1038/s41598-026-45925-z.
Xuan Zhu  #  1  2 ,  Yuhan Zhou  #  3 ,  Mingyu Ruan  #  3 ,  Xuebin Yang  4  5 ,  Gang Pei  #  6  7 ,  Jin Tan  #  8
Affiliations
  • 1. Department of Science and Technology, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 2. Department of Stomatology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410021, China.
  • 3. School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 4. College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 5. Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha, 410208, China.
  • 6. College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. [email protected].
  • 7. Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha, 410208, China. [email protected].
  • 8. Department of Stomatology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410021, China. [email protected].
  • # Contributed equally.
PMID: 41917130 DOI: 10.1038/s41598-026-45925-z
Keywords
Liver fibrosis; Macrophage; Oral submucous fibrosis; Pomolic acid; Pro-fibrotic macrophage polarization; β-arrestin 2.
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