1. GPCR/G Protein
  2. Leukotriene Receptor
  3. Tipelukast

Tipelukast (Synonyms: KCA 757; MN 001)

Cat. No.: HY-14938
Handling Instructions

Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.

For research use only. We do not sell to patients.

Tipelukast Chemical Structure

Tipelukast Chemical Structure

CAS No. : 125961-82-2

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Description

Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.

IC50 & Target

LTD4

6.41 (pA2, In guinea-pigs)

LTE4

6.45 (pA2, In guinea-pigs)

In Vitro

Tipelukast inhibits the binding of [3H] LTD4 to the LTD4 receptors on pul-monary cell membrane of guinea-pigs (IC50 = 2.3 μmol)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

530.67

Formula

C₂₉H₃₈O₇S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Tipelukast
Cat. No.:
HY-14938
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