Cat. No.: HY-N7905

Myricetin 3'-glucoside

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Myricetin 3'-glucoside is an orally active glycosylated flavonoid. Myricetin 3'-glucoside inhibits the cerebral ischemia-induced elevation of inflammatory cytokine levels, including TNF-α, IL-6 and IL-1β. Myricetin 3'-glucoside reverses the cerebral ischemia-mediated downregulation of Bcl-2 protein levels and reduces the cerebral ischemia-induced upregulation of Bax protein levels. Myricetin 3'-glucoside reduces cerebral infarct volume, increases the number of Nissl bodies, and improves neurological function scores in a rat model of middle cerebral artery occlusion (MCAO). Myricetin 3'-glucoside can be used in cerebral ischemia-related research.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 520-14-9
Formula: C₂₁H₂₀O₁₃
Molecular Weight:480.38

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Myricetin 3'-glucoside Chemical Structure

CAS No.: 520-14-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Bcl-2

Bax

IL-6

IL-1β

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All Bcl-2 Family Isoforms :

In Vivo

Myricetin 3'-glucoside (5 mg/kg; i.g.; single administration) exerts neuroprotective effects against cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats, 9 weeks old, with a body weight ranging from 230 to 255 grams.^[1]
Dosage:

5 mg/kg
Administration:

i.g.; single administration
Result:

Reduced the volume of cerebral infarction.
Improved neurological deficits, manifested as improved walking, balance and sensory reflexes.
Protected neurons, manifested by an increase in Nissl bodies.
Inhibited TNF-α, IL-6, and IL-1β, upregulate Bcl-2, downregulate Bax, and restore the ratio of Bcl-2/Bax.

Chemical Information

CAS No. 520-14-9
Appearance Solid
Molecular Weight 480.38
Formula C₂₁H₂₀O₁₃
Color Off-white to light yellow
SMILES

O=C1C(C(OC(C(C=C2O)=CC(O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)=C2O)=C1O)=CC(O)=C4)=C4O
Structure Classification
- Flavonoids
- Flavonols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (104.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0817 mL

10.4084 mL

20.8169 mL

5 mM

0.4163 mL

2.0817 mL

4.1634 mL

10 mM

0.2082 mL

1.0408 mL

2.0817 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ye, S., et al. (2020). Neuroprotective and anti-inflammatory effects of myricetin 3-glucoside in a rat model of cerebral ischemia. Tropical Journal of Pharmaceutical Research, 19(8), 1709-1714.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0817 mL	10.4084 mL	20.8169 mL	52.0421 mL
	5 mM	0.4163 mL	2.0817 mL	4.1634 mL	10.4084 mL
	10 mM	0.2082 mL	1.0408 mL	2.0817 mL	5.2042 mL
	15 mM	0.1388 mL	0.6939 mL	1.3878 mL	3.4695 mL
	20 mM	0.1041 mL	0.5204 mL	1.0408 mL	2.6021 mL
	25 mM	0.0833 mL	0.4163 mL	0.8327 mL	2.0817 mL
	30 mM	0.0694 mL	0.3469 mL	0.6939 mL	1.7347 mL
	40 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3011 mL
	50 mM	0.0416 mL	0.2082 mL	0.4163 mL	1.0408 mL
	60 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8674 mL
	80 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6505 mL
	100 mM	0.0208 mL	0.1041 mL	0.2082 mL	0.5204 mL

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Myricetin 3'-glucoside

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All TNF Receptor Isoforms

All Interleukin Related Isoforms

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Myricetin 3'-glucoside Related Classifications

HY-N7905 Related Classifications