Fanetizole
Based on 1 Customer Validation
Fanetizole is an anti-inflammatory agent. Fanetizole can be used for inflammatory diseases research.
For research use only. We do not sell to patients.
- Purity : 98.11%
- CAS No.: 79069-94-6
- Formula: C17H16N2S
- Molecular Weight:280.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 79069-94-6
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Appearance Solid
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Molecular Weight 280.39
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Formula C17H16N2S
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Color Yellow to brown
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SMILES
C1(NCCC2=CC=CC=C2)=NC(C3=CC=CC=C3)=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 27.5 mg/mL (98.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5665 mL | 17.8323 mL | 35.6646 mL | 89.1615 mL |
| 5 mM | 0.7133 mL | 3.5665 mL | 7.1329 mL | 17.8323 mL | |
| 10 mM | 0.3566 mL | 1.7832 mL | 3.5665 mL | 8.9162 mL | |
| 15 mM | 0.2378 mL | 1.1888 mL | 2.3776 mL | 5.9441 mL | |
| 20 mM | 0.1783 mL | 0.8916 mL | 1.7832 mL | 4.4581 mL | |
| 25 mM | 0.1427 mL | 0.7133 mL | 1.4266 mL | 3.5665 mL | |
| 30 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9721 mL | |
| 40 mM | 0.0892 mL | 0.4458 mL | 0.8916 mL | 2.2290 mL | |
| 50 mM | 0.0713 mL | 0.3566 mL | 0.7133 mL | 1.7832 mL | |
| 60 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL | |
| 80 mM | 0.0446 mL | 0.2229 mL | 0.4458 mL | 1.1145 mL |
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