1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Apoptosis
  2. Calcium Channel
    Apoptosis
  3. Cycleanine

Cycleanine 

Cat. No.: HY-N2005
Handling Instructions

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.

For research use only. We do not sell to patients.

Cycleanine Chemical Structure

Cycleanine Chemical Structure

CAS No. : 518-94-5

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Description

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

In Vitro

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.
In Vivo

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

622.75

Formula

C₃₈H₄₂N₂O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Cycleanine
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HY-N2005
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